doi:10.11852/zgetbjzz2015-23-06-13

Abstract

摘要： 双酚A是世界范围内生产量最大的化合物之一,年生产总量超过60亿磅,主要用于制造聚碳酸酯塑料和环氧树脂,继而被广泛用于人们日常生活中,每年有超过100吨的双酚A释放到大气中。双酚A结构与雌二醇相似,具有微弱的拟雌激素活性和较强的抗雄激素作用,因此被认为是一种内分泌干扰化合物。目前研究表明,双酚A与一些疾病的发生有关,如泌尿生殖系统、内分泌系统及心血管系统等疾病。其中,双酚A与儿童肥胖症的关系日益受到关注。双酚A可能通过拟雌激素作用、拟糖皮质激素作用、调控肥胖相关基因表达抑或直接作用于前脂肪细胞等途径促进脂肪生成或堆积,导致肥胖的发生。这里主要对儿童双酚A暴露,及其与肥胖的关系进行总结。

关键词: 双酚A, 肥胖症, 儿童

CLC Number:

R723.14

王盈灿综述, 沈理笑审校. 双酚A暴露与儿童肥胖关系的研究进展[J]. 中国儿童保健杂志, 2015, 23(6): 601-603.

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双酚A暴露与儿童肥胖关系的研究进展

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