Abstract: Objective To explore the effect of intestinal flora imbalance on immune function in children with recurrent respiratory tract infection (RRTI). Methods The objects of observation were RRTI children of shelter treatment in Yidu Central Hospital of Weifang and Qingzhou Traditional Chinese Hospital from May 2014 to September 2016,and divided into the group of flora imbalance,non flora imbalance group by the existence of intestinal flora imbalance.The control group were 80 cases of children without RRTI by random extraction.The situation of bacterial flora imbalance were compared in different age groups. Results RRTI group was significantly higher than the control group in incidence rate of flora imbalance,especially in the age of 3,3~6 years old of age,this was statistically significant(P<0.05).RRTI group was significantly lower than the control group in IgA level in the age of 3,3~6 years old of age,this was statistically significan(P<0.05).There was no significant difference between the two groups in IgM level,IgG level(P>0.05). Conclusions Intestinal flora imbalance may be an important risk factor with RRTI in children under 6 years old,this may be related to the reduction of immunoglobulin after flora imbalance.Timely detection of intestinal flora,improvement of intestinal micro ecological environment have a positive meaning to prevention of RRTI.

Key words: flora imbalance, recurrent respiratory tract infection, immune function

摘要： 目的 分析肠道菌群失调对反复呼吸道感染(RRTI)儿童免疫功能的影响,为RRTI的防治提供参考。方法 选取2014年5月-2016年9月期间在潍坊市益都中心医院及青州市中医院就诊的RRTI的儿童,根据是否存在肠道菌群失调又分为菌群失调组和非菌群失调组,随机抽取在同时期内到医院就诊的非RRTI 80例作为对照组,对比＜3岁、3~6岁、＞6岁年龄段的各组儿童肠道菌群失调的情况,同时对比其免疫球蛋白水平。结果 RRTI组菌群失调发生率明显高于对照组,尤其是在＜3岁、3~6岁年龄段,差异具有统计学意义(P<0.05),RRTI组在＜3岁、3~6岁年龄段的IgA水平明显低于对照组,差异均有统计学意义(P<0.05),IgM、IgG差异无统计学意义(P>0.05)。结论 肠道菌群失调可能是6岁以下儿童RRTI的一个重要危险因素,这可能与肠道菌群失调后造成的免疫球蛋白的降低有关,及时检测肠道菌群、改善肠道微生态环境对预防RRTI的发生有积极的意义。

关键词: 菌群失调, 反复呼吸道感染, 免疫功能