Abstract: Objective To analyze the relationship between serum vitamin A level and recurrent respiratory tract infection (RRTI) in children, so as to provide reference for the prediction of vitamin A as a risk of RRTI and the adjuvant treatment of RRTI. Methods A total of 120 children with RRTI admitted to the second pediatrics department of the Fourth Affiliated Hospital of China Medical University were selected as observation group from August 2017 to August 2018.And the other 120 children with respiratory infection admitted to the hospital in the same period were selected as the control group.The levels of vitamin A and immunoglobulin (IgA, IgG, IgM) in two groups were analyzed and compared.And the relationship between vitamin A and immunoglobulin was analyzed.Children with RRTI were followed up for one year, exogenous vitamin A supplementation was recorded after discharge, and the number of RRTI was observed. Results The serum vitamin A level of the observation group was lower than that of control group, and the detection rate of subclinical vitamin A deficiency in the observation group was higher than that of control group (t=2.632, χ²=7.366, P<0.05).The IgG level in the vitamin A deficiency group was significantly lower than that in children with normal vitamin A level (F=5.036, P＜0.05).Pearson analysis showed that vitamin A level was positively correlated with IgG level (r=0.172, P<0.05).There was no significant difference on the number of respiratory infections between the groups with vitamin A supplementation and without vitamin A supplementation before treatment (P>0.05).After treatment, the number of respiratory infection in both groups was significantly reduced (t=9.291, 2.036, P<0.05), and it was less in the group with vitamin A supplementation than group without vitamin A supplementation (t=2.448, P＜0.05). Conclusion RRTI is associated with vitamin A deficiency, and vitamin A supplementation can be helpful to reduce respiratory infection.

Key words: vitamin A, immunoglobulin, recurrent respiratory tract infection, children

摘要： 目的 分析儿童血清维生素A与反复呼吸道感染之间的关系, 为维生素A预测及辅助治疗反复呼吸道感染提供依据。方法 选取2017年8月-2018年8月中国医科大学附属第四医院第二儿科收治的120例反复呼吸道感染患儿为观察组, 另取同期该院收治的120例呼吸道感染患儿为对照组, 检测两组患儿维生素A及免疫球蛋白(IgA、IgG、IgM)水平, 比较两组间维生素A水平的差异, 对维生素A 及免疫球蛋白进行相关分析, 并对观察组出院后随访1年, 记录出院后补充外源性维生素A的情况, 观察呼吸道感染的复发次数。结果 观察组患儿的维生素A水平低于对照组, 且观察组的亚临床型维生素A缺乏检出率高于对照组(t=2.632、χ²＝7.366, P＜0.05)。维生素A缺乏组患儿的IgG水平低于维生素A正常组 (F＝5.036, P＜0.05)。Pearson相关性分析显示, 维生素A与IgG呈正相关(r=0.172, P＜0.05)。治疗前, 补充维生素A组与未补充维生素A组患儿的呼吸道感染次数差异无统计学意义(P＞0.05);治疗后, 两组患儿的呼吸道感染次数均显著减少(t=9.291、2.036, P＜0.05), 且补充维生素A组少于未补充维生素A组(t=2.448, P＜0.05)。结论 反复呼吸道感染与维生素A缺乏有关, 补充维生素A有助于减少呼吸道感染的发生。

关键词: 维生素A, 免疫球蛋白, 反复呼吸道感染, 儿童