journal1 ›› 2017, Vol. 25 ›› Issue (12): 1288-1289.DOI: 10.11852/zgetbjzz2017-25-12-28

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Effect and clinical significance of GnGHa therapy on serum levels of P1NP, β-CTX and N-MID in idiopathic central precocious puberty girls

WANG Yan-hua, ZHAO Xin   

  1. Deparment of Pediatrics,the Affiliated Hospital of the Armed Police Logistics College,Tianjin 300162,China
  • Received:2017-04-10 Online:2017-12-10 Published:2017-12-10


王琰华, 赵忻   

  1. 武警后勤学院附属医院儿科,天津 300162
  • 作者简介:王琰华(1984-),女,天津人,医师,硕士学位,主要研究方向为儿童呼吸道、消化道常见病,急诊急救中毒和性早熟等。

Abstract: Objective To investigate the effect of gonadotropin-releasing hormone analogue (GnRHa) on serum levels of P1NP,β-CTX,N-MID level in idiopathic central precocious puberty (ICPP) girls. Methods Totally 102 cases of ICPP girls in the Affiliated Hospital of the Armed Police Logistics college hospital were selected as the subjects,and were treated with GnRHa.The growth condition,hormone level and bone metabolism before and after treatment were compared. Results BMI and the level of PAH after treatment were significantly higher than those before treatment,and the volume of uterus and ovarian decreased significantly (P<0.05);The level of P-LH,P-FSH,E2 after treatment were significantly reduced than those before treatment (P<0.05);There was no significant difference on the β-CTX level between before and after treatment (P>0.05),and the level of P1NP,N-MID were significantly reduced than those before treatment (P<0.05). Conclusion GnRHa is an effective therapy on the treatment of ICPP girls,and can significantly improve the body hormone level,inhibit osteoblast function,and improve bone metabolism.

Key words: gonadotropin releasing hormone analogue, idiopathic central precocious puberty, girls, bone metabolism

摘要: 目的 分析促性腺激素释放激素类似物(GnRHa)对特发性中枢性性早熟(ICPP)女童血清P1NP、β-CTX、N-MID水平的影响。方法 选取本院102例ICPP女童作为研究对象,予以GnRHa治疗,对比治疗前后生长发育情况、激素水平、骨代谢水平。结果 治疗后的BMI、PAH水平较治疗前显著升高,而子宫容积、卵巢容积显著变小,差异有统计学意义(P<0.05);治疗后的P-LH、P-FSH、E2水平较治疗前显著降低,差异有统计学意义(P<0.05);治疗前后的β-CTX水平无显著差异(P>0.05),而P1NP、N-MID水平较治疗前显著降低,差异有统计学意义(P<0.05)。结论 GnRHa在治疗ICPP女童方面疗效显著,可显著改善机体激素水平,抑制成骨细胞功能,改善患儿骨代谢水平。

关键词: 促性腺激素释放激素类似物, 特发性中枢性性早熟, 女童, 骨代谢

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