Abstract: Objective To analyse the imaging features of the girls with idiopathic central precocious puberty (ICPP) and premature thelarche (PT),and to explore the role of the magnetic resonance imaging (MRI) in the differential diagnosis.Methods A total of 35 girls with ICPP and 35 PT girls which from a provincial hospital in Henan were selected as observed objects,all the children had MRI scans of the cranial saddle area and the pituitary height were measured,and the developmental level of the pituitary gland was divided by Elster law. Results The mean value of pituitary height of ICPP group was (5.18±1.01) mm and (4.30±0.38) mm of the PT group,there was a statistically significant difference between the two groups (P<0.05);The Elster's grade of pituitary morphology which was equal or greater than IV grade of ICPP group and the PT group were accounted for 82.86% and 11.43% respectively (P<0.05).Conclusion s The pituitary height in ICPP group is higher,the upper edge of the pituitary Morphology is full;The pituitary height in PT group is lower,the upper edge of the pituitary Morphology is mainly flat or low-lying.The examination of the pituitary by MRI is non-invasive and painless,and has important reference value in the differential diagnosis between ICPP and PT,and it can be used as the auxiliary examination of the precocious puberty.

Key words: magnetic resonance imaging, idiopathic central precocious puberty, premature thelarche, differential diagnosis

摘要： 目的 分析特发性性早熟(idiopathic central precocious puberty,ICPP)和单纯乳房早发育(premature thelarche,PT)女童的磁共振(magnetic resonance imaging,MRI)影像学特点,探讨MRI在两者鉴别诊断中的价值。方法 以在河南某省级医院确诊的ICPP女童和PT女童各35例作为研究对象,均行头颅鞍区磁共振扫描,测量MRI脑垂体高度,Elster法划分脑垂体发育等级。结果 垂体高度:ICPP组的均值为(5.18±1.01)mm,PT组(4.30±0.38)mm,差异有统计学意义(P<0.05);垂体形态:ICPP组Ⅳ级及以上的占82.86%,PT组Ⅳ级及以上占11.43%(P<0.05)。结论 ICPP组患儿的垂体偏高,上缘饱满;PT组患儿垂体偏低,以上缘扁平或低凹为主。磁共振脑垂体检查对ICPP与PT鉴别诊断有重要参考价值,无创无痛,可作为性早熟初诊的辅助检查。

关键词: 核磁共振, 特发性性早熟, 单纯乳房早发育, 鉴别诊断