journal1 ›› 2018, Vol. 26 ›› Issue (11): 1199-1202.DOI: 10.11852/zgetbjzz2018-26-11-10

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Research progress on the influencing factors and related pathogenesis mechanism of neural tube defects

JIANG Chun-qian1, LI Yan-ping1, GUO Shuang2, SONG Ying-dong1, XU Ding1   

  1. 1 Department of Pediatrics Lanzhou University Second Hospital, Lanzhou, Gansu 730030,China;
    2 Department of Urology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030,China
  • Received:2018-05-25 Revised:2018-07-03
  • Contact: XU Ding,



  1. 兰州大学第二医院 1儿科,甘肃 兰州 730030;
    2 泌尿外科,甘肃 兰州 730030
  • 通讯作者: 徐丁,
  • 作者简介:姜春倩(1993-),女,山东人,在读硕士,主要研究方向为先天性疾病防治

Abstract: Neural tube defects (NTDs) are severe congenital malformations that originated in the process of embryogenesis, and are the result of an abnormal process of neural tube closure. NTDs are caused by multiple factors, including genetic factors, environmental factors, and the interaction between genetics and the environment. Folic acid supplementation may reduce the incidence, but the mechanism is not yet clear, and the occurrence of NTDs is also related to other factors. This review summarizes research progress on the factors associated with NTDs and the related pathogenesis mechanism.

Key words: neural tube defects, gene, environment, mechanism, research progress

摘要: 神经管畸形(NTDs)是严重的先天性畸形之一,起源于胚胎发生过程,是神经管闭合过程异常的结果。其发病由多种因素引起,包括遗传因素、环境因素以及遗传与环境之间的相互作用等,叶酸的补充虽可降低其发病率,但机制尚不完全明确,并且NTDs的发生也与其他因素相关。本文就神经管畸形的影响因素及相关发病机制研究进展作一综述。

关键词: 神经管畸形, 遗传, 环境, 机制, 研究进展

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