Analysis on the effect of GnRHa on improving final adult height and related factors in girls  with idiopathic central precocious puberty

doi:10.11852/zgetbjzz2018-0585

journal1 ›› 2019, Vol. 27 ›› Issue (3): 262-264.DOI: 10.11852/zgetbjzz2018-0585

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Analysis on the effect of GnRHa on improving final adult height and related factors in girls with idiopathic central precocious puberty

XU Hui-jie¹,YE Jin¹,YUAN Xue-jing¹,CAO Jian-mei¹,LI Hui¹,ZHANG Yu²

1 Department of Pediatrics,the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing, Jiangsu 210029,China;
2 Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210029,China Corresponding auther:YE Jin,E-mail:dryejin@126.com

Received:2018-05-04 Revised:2018-10-09 Online:2019-03-20 Published:2019-03-20

促性腺激素释放激素类似物改善特发性中枢性性早熟女童成年身高及相关因素分析

许慧洁¹,叶进¹,袁雪晶¹,曹建梅¹,李辉¹,张俞²

1.南京中医药大学附属医院儿科,江苏南京 210029;
2.南京中医药大学,江苏南京 210029

通讯作者: 叶进,E-mail:dryejin@126.com
作者简介:许慧洁(1987-),女,河南人,主治医师,硕士学位,主要研究方向为儿童内分泌疾病。
基金资助:
江苏省中医药局项目(LZ11043);南京中医药大学中医儿科重点学科开放课题项目研究计划(EZK2009015)

Abstract

Abstract: Objective To evaluate the effect of gonadotropin-releasing hormone analogues(GnRHa) on improving final adult height(FAH) in girls with idiopathic central precocious puberty(ICPP),and to analyze the related factors. Methods Data of 26 ICPP girls,who had been treated with GnRHa alone and had reached or approached their FAH in the affiliated hospital of Nanjing Unversity of traditonal Chinese medicine from May, 2009 to July,2011,were retrospectively analyzed. Results The 26 girls with ICPP were treated by GnRHa for(22.50±5.48)months,followed up for(58.0±7.44)months,and finally the mean FAH was(161.50±4.41)cm,significantly higher than the prediction of adult height before treatment [(157.23±5.51)cm,P<0.01].The net height gain was(4.27±4.05)cm.The body mass index(BMI) before treatment,at the end of treatment and after reaching FAH was(16.32±1.67)kg/m²,(17.39±2.41)kg/m² and(19.95±2.21)kg/m² respectively,and all remained in the nomal range of age(±1s).The average menstrual age of 26 ICPP girls was(12.5±0.7)years old.The FAH was positively correlated with height when the medication stopped and menarche age(P<0.01 or <0.05),and negatively related to bone age when medication stopped(P<0.01). Conclusion GnRHa can significantly improve the final height in girls with ICPP,and the FAH is correlated with the height,bone age when the medication stopped,and menarche age.Moreover,youth development of children after medication stopped is similar to that of the normal children.

Key words: gonadotropin-releasing hormone analogues, idiopathic central precocious puberty, girls, final adult height

摘要： 目的观察促性腺激素释放激素类似物(GnRHa)治疗特发性中枢性性早熟(ICPP)女童改善成年身高(FAH)的疗效,并分析其相关影响因素。方法回顾性分析2009年5月-2011年7月南京中医药大学附属医院就诊的26例单独应用GnRHa治疗,并已达或接近FAH的ICPP女童生长发育资料。结果经GnRHa治疗(22.50±5.48)月,并随访(58.00±7.44)月,26例ICPP女童FAH为(161.50±4.41)cm,较治疗开始时预测成年身高(157.23±5.51)cm显著增高(P<0.01),身高净获(4.27±4.05)cm。治疗前、治疗终止时患儿体重指数(BMI)为(16.32±1.67)kg/m²、(17.39±2.41)kg/m²,达到FAH时BMI为(19.95±2.21)kg/m²,均在与年龄相应的±1s范围。26例ICPP女童月经来潮年龄(12.5±0.7)岁。FAH的最终获得与停药时身高、初潮年龄呈正相关(P<0.01或<0.05),与停药时骨龄呈负相关(P<0.01)。结论 GnRHa对改善ICPP女童FAH有显著疗效,FAH的最终获得与停药时身高、停药时骨龄及初潮年龄相关,停药后患儿青春发育与正常儿童相似。

关键词: 促性腺激素释放激素类似物, 特发性中枢性性早熟, 女童, 成年身高

CLC Number:

R179

XU Hui-jie,YE Jin,YUAN Xue-jing,CAO Jian-mei,LI Hui,ZHANG Yu. Analysis on the effect of GnRHa on improving final adult height and related factors in girls with idiopathic central precocious puberty[J]. journal1, 2019, 27(3): 262-264.

许慧洁,叶进,袁雪晶,曹建梅,李辉,张俞. 促性腺激素释放激素类似物改善特发性中枢性性早熟女童成年身高及相关因素分析[J]. 中国儿童保健杂志, 2019, 27(3): 262-264.

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Analysis on the effect of GnRHa on improving final adult height and related factors in girls with idiopathic central precocious puberty

促性腺激素释放激素类似物改善特发性中枢性性早熟女童成年身高及相关因素分析

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