Analysis of current level and related factors of vitamin A in 212 cases of hospitalized newborns

doi:10.11852/zgetbjzz2018-0226

Abstract

Abstract: Objective To evaluate the level of plasma vitamin A(VA) and the influencing factors of VA level in 212 hospitalized newborns. Methods The plasma level of VA in newborns was tested by high performance liquid chromatography(HPLC) from June to December 2017.And the general data of children were collected.SPSS 19.0 were used to analyze the influencing factors of VA level. Results There were 189(89.1%) cases were detected with VA deficiency. Gender,age,blood glucose,infection and neonatal respiratory distress syndrome(NRDS) were factors influencing VA concentration,and the difference was statistically significant(P<0.05). The level of VA was negatively correlated with C-reaction protein(CRP)(r=-0.167,P=0.015). The correlation between mother and neonates was not statistically significant(P＞0.05).Gender(OR=0.465,95%CI:0.237-0.913,P=0.026) and infection(OR=2.583,95%CI:1.135-5.876,P=0.024) were the risk factors for clinical VA deficiency. Conclusion Vitamin A deficiency in newborns is severe. Male infants and newborns with infection are prone to developing clinical vitamin A deficiency.

Key words: vitamin A, sex, infection, hospitalized newborns

摘要： 目的分析212例住院新生儿血浆维生素A(VA)浓度及各种因素对VA浓度的影响,为临床干预提供理论依据。方法采用高效液相色谱法检测2017年6-12月212例住院新生儿血浆VA浓度。并收集新生儿的基本资料。采用SPSS 19.0统计软件分析各种因素对VA浓度影响。结果 VA缺乏(VAD)189例,比例达89.1%;性别、年龄、血糖、感染、新生儿呼吸窘迫综合征(NRDS)均为影响VA浓度的因素,差异有统计学意义(P<0.05);VA水平与C反应蛋白呈负相关(r=-0.167,P=0.015);母亲VA水平与新生儿VA水平无相关性(P>0.05);性别(OR=0.465,95%CI:0.237~0.913,P=0.026)、感染(OR=2.583,95%CI:1.135~5.876,P=0.024)是临床VAD危险因素。结论晋城市新生儿VA缺乏状况较严重,男婴感染的新生儿更容易发生临床VA缺乏。

关键词: 维生素A, 性别, 感染, 住院新生儿

CLC Number:

R179

CHANG Xiao,WANG Zhe,WU Yun-xia. Analysis of current level and related factors of vitamin A in 212 cases of hospitalized newborns[J]. journal1, 2019, 27(3): 330-332.

常晓,王哲,吴云霞. 住院新生儿212例维生素A水平及相关因素分析[J]. 中国儿童保健杂志, 2019, 27(3): 330-332.

References

[1] Stevens GA,Bennett JE,Hennocq Q,et al.Trends and mortality effects of vitamin A deficiency in children in 138 low-income and middle-income countries between 1991 and 2013:a pooled analysis of population-based surveys[J].Lancet Glob Health,2015,3(9):e528-536.
[2] Barber T,Esteban-Pretel G,Marín MP,et al.Vitamin a deficiency and alterations in the extracellular matrix[J].Nutrients,2014,6(11):4984-5017.
[3] Esteban-Pretel G,Marin MP,Rrnsu-Piqueras J,et al.Vitamin A deficiency alters rat lung alveolar basement membrane:reversibility by retinoic acid[J].Nutr Biochem,2010,21(3):227-236.
[4] Esteban-Pretel G1,Marín MP,Renau-Piqueras J,et al.Vitamin A deficiency disturbs collagen IV and laminin composition and decreases matrix metalloproteinase concentrations in rat lung.Partial reversibility by retinoic acid[J].J Nutr Biochem, 2013,24(1):137-145.
[5] 刘霞,李廷玉,陈洁.维生素A缺乏影响肠道屏障功能的研究进展[J].生命科学,2012,24(1):32-36.
[6] Ozdemir R,Yurttutan S,Sari FN,et al.All-trans-retinoic acid attenuates intestinal injury in a neonatal rat model of necrotizing enterocolitis[J],Neonatology,2013,104(1):22-27.
[7] Mactier H,McCulloch DL,Hamilton R,et al.Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity[J].J Pediatr,2012,160(6):954-959.
[8] Meyer S,Gortner L.Early postnatal additional high-dose oral vitamin A supplementatian versus placebo for 28 days for preventing bronchopulmonary dysplasia or death in extremely low birth weight infants[J].Neonatology,2014,105(3):182-188.
[9] Sirisinha S.The pleiotropic role of vitamin A in regulating mucosal immunity[J].Asian Pac J Allergy Immunol,2015,33(2):71-89.
[10] 顾志勇,余加林.维生素A与新生儿肺炎、败血症及呼吸窘迫综合征相关性的临床研究[J].儿科药学杂志,2015,6(21):11-14.
[11] 胡亚美.诸福棠实用儿科学[M].北京:人民卫生出版社,2015:556.
[12] Thorne-Lyman AL,Fawzi WW.Vitamin A and carotenoids during pregnancy and maternal,neonatal and infant health outcomes:a systematic review and meta-analysis[J].Paediatr Perinat Epidemiol,2012,26(1):36-54.
[13] 李文迪,魏守磊,彭云.新生儿维生素A缺乏的研究进展[J].中国儿童保健杂志,2017,8(25):799-802.
[14] 陶恩福,袁天明.维生素A水平与早产儿疾病[J].中国当代儿科杂志,2016,2(18):177-182.
[15] 刘登礼,何必子.不同胎龄和不同出生体重新生儿出生时血清维生素A水平测定[J].中国新生儿科杂志,2015,30(5):358-360.
[16] 孟君,吴洪涛.新生儿呼吸窘迫综合征维生素A、矿物质水平的研究[J].中国儿童保健杂志,2015,23(11):1221-1223.
[17] Ruttenstock EM,Doi T,Dingemann J,et al.Prenatal retinoicacid upregulates connexin 43(Cx43) gene expression in pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia rat model[J].J Pediatr Surg,2012,47(2):336-340.