Abstract: Objective To analyze the characteristics of suspected adverse event following immunization (AEFI) in Anshan City during 2015-2018, so as to evaluate the safety of national immunization program vaccines. Methods The AEFI case data of Anshan City during 2015-2018, collected by the AEFI information management system were analyzed by descriptive epidemiological method. Results A total of 863 AEFI cases caused by immunization program vaccines for children were reported in Anshan during 2015-2018, with 199 cases in 2015, 231 cases in 2016, 170 cases in 2017 and 263 cases in 2018.The overall reported incidence was 42.53/10⁵.Among all the reported cases, 796(92.24%) cases were common adverse reactions, 39(4.52%) cases were rare adverse reactions, 26(3.01%) cases were coincidental events, and 1(0.12%) case was psychogenic reaction, 1(0.12%) case was undetermined.A total of 649(75.20%) cases occurred among children under one year old.The vaccine with the highest reported number and incidence of AEFI was the DTaP vaccine, reported by 336 cases (93.19/10⁵). Conclusion AEFI monitoring in Anshan is of high sensitivity, and national immunization program vaccines for children are highly safe.

Key words: suspected adverse events following immunization, national immunization program vaccine, monitoring

摘要： 目的 通过分析鞍山市2015-2018年疑似预防接种异常反应(AEFI)的发生特征, 评价鞍山市儿童免疫规划疫苗的安全性。方法 通过AEFI信息管理系统收集2015-2018年鞍山市AEFI个案数据, 采用描述性流行病学方法进行分析。结果 鞍山市2015-2018年累计报告儿童免疫规划疫苗AEFI病例863例, 其中2015年报告199例、2016年报告231例、2017年报告170例、2018年报告263例。总报告发生率为42.53/10⁵, 其中一般反应796例, 占92.24%;异常反应39例, 占4.52%;偶合症26例, 占3.01%;心因性反应1例, 占0.12%;待定1例, 占0.12%。0~1岁年龄段共报告649例, 占总报告数的75.20%。报告数和发生率最高的疫苗为吸附无细胞百白破联合疫苗, 报告336例(93.19/10万)。结论 鞍山市AEFI监测灵敏度较高, 儿童免疫规划疫苗安全性较好。

关键词: 疑似预防接种异常反应, 免疫规划疫苗, 监测