Research progress on the role of nutritional supplements in the treatment of attention deficit hyperactivity disorder in children

doi:10.11852/zgetbjzz2019-1444

Abstract

Abstract: Attention deficit hyperactivity disorder(ADHD) is a common neurobehavioral disorder in children and adolescents,which may persist into adulthood.Insufficient supply of polyunsaturated fatty acids (PUFA) and minerals such as zinc,iron and magnesium has been considered to play an important role in the development of ADHD symptoms.This article reviews the research progress on PUFA and mineral nutrition supplements in the treatment of ADHD,and encourages clinicians to take appropriate screening and preventive measures on the basis of reviewing the dietary history of children with ADHD,so as to provide individualized treatment strategies for ADHD children.

Key words: attention deficit hyperactivity disorder, nutritional supplements, children

摘要： 注意缺陷多动障碍(ADHD)是一种常见的儿童和青少年神经行为障碍性疾病,可能会持续到成年。多不饱和脂肪酸(PUFA)和锌、铁、镁等矿物质供应不足被认为在ADHD症状的发展中发挥重要作用。本文综述了PUFA和矿物质营养补充剂治疗ADHD的相关研究进展,鼓励临床医生在回顾患儿饮食历史的基础上,采取适当的筛查和预防性措施,为ADHD患儿提供个性化治疗策略。

关键词: 注意缺陷多动障碍, 营养补充剂, 儿童

CLC Number:

R749.94

ZHANG Yang, HU Bin, ZHANG Yu-ping. Research progress on the role of nutritional supplements in the treatment of attention deficit hyperactivity disorder in children[J]. journal1, 2020, 28(12): 1351-1354.

张杨, 胡斌, 张雨平. 营养补充剂治疗儿童注意缺陷多动障碍的研究进展[J]. 中国儿童保健杂志, 2020, 28(12): 1351-1354.

References

[1] Lange KW,Hauser J,Lange KM,et al.Utility of cognitive neuropsychological assessment in attention-deficit/hyperactivity disorder[J].Atten Defic Hyperact Disord,2014,6(4):241-248.
[2] Aretouli E.How neuropsychology can inform our understa nding of preschool ADHD:Clinical and research implications[J].Appl Neuropsychol Child,2019,8(2):174-181.
[3] 方圆,王瑜.儿童注意缺陷多动障碍与过敏性疾病的相关性研究[J].中国儿童保健杂志,2019,29(7):982-985.
[4] 阎樱,王亚萍.哌醋甲酯对ADHD动物模型SHR大鼠前额叶皮质层细胞凋亡的影响[J].中国妇幼健康研究,2016,27(12):1450-1452.
[5] Bussing R,Zima BT,Gary FA,et al.Use of complementary and alternative medicine forsymptoms of attention-deficit hyperactivity disorder[J].Psychiatr Serv,2002,53(9):1096-1102.
[6] Scholle O,Jilani H,Riedel O,et al.Use of nutritional supplements in youth with medicated and unmedicated attention-deficit/hyperactivity disorder[J].J Child Adolesc Psychopharmacol,2019,29(1):58-65.
[7] Parletta N,Niyonsenga T,Duff J.Omega-3 and omega-6 polyunsaturated fatty acid levels and correlations with symptoms in children with attention deficit hyperactivity disorder,autistic spectrum disorder and typically developing controls[J].PLoS ONE,2016,11(5):e0156432.
[8] Schuchardt JP,Huss M,Stauss-Garbo M,et al.Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviourof children[J].Eur J Pediatr,2010,169(2):149-164.
[9] Shahraki AD,Dehkordi NZ,Lotfizadeh M.Comparison of high dose and low dose folic acid supplementation on prevalence,onset and severity of preeclampsia[J].Adv Biomed Res,2016,5:192.
[10] Keim SA,Garcious B,Boone KM,et al.ω-3 and ω-6 fatty acid supplementation may reduce Autism symptoms based on parent report in preterm toddlers[J].J Nutr,2018,148(2):227-235.
[11] Agostoni C,Nobile M,Ciappolino V,et al.The role of omega-3 fatty acids in Developmental psychopathology:a systematic review on early psychosis,autism,and ADHD[J].Int J Mol Sci,2017,18(12):E2608.
[12] Hawkey E,Nigg JT.Omega-3 fatty acid and ADHD:blood level analysis and meta-analytic extension of supplementation trials[J].Clin Psychol Rev,2014,34(6):496-505.
[13] Checa-Ros A,Haro-Garica A,Seiquer I,et al.Early monitoring of fatty acid profile in children with attention deficit and/or hyperactivity disorderunder treatment with omega-3 polyunsaturated fatty acids[J].Minerva Pediatr,2019,71(4):131-325.
[14] Widenhorn-Müller K,Schwanda S,Scholz E,et al.Effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit/hyperactivity disorder (ADHD):a randomized placebo-controlled intervention trial[J].Prostaglandins Leukot Essent Fatty Acids,2014,91(1-2):49-60.
[15] Bos DJ,Oranje B,Veerhoek ES,et al.Reduced symptoms of inattention after dietary omega- 3 fatty acid supplementation in boys with and without attention deficit/hyperactivity disorder[J].Neuropsychopharmacology,2015,40(10):2298-2306.
[16] 刘建英,刘咏梅,陶芳,等.ω-3多不饱和脂肪酸联合哌甲酯治疗注意缺陷多动障碍患儿的初步研究[J].广东医学,2017,38(4):615-619.
[17] Milte CM,Parletta N,Buckley JD,et al.Eicosapentaenoic and docosahexaenoic acids,cognition,and behavior in children with attention-deficit/hyperactivity disorder:a randomized controlled trial[J].Nutrition,2012,28(6):670-677.
[18] Matsudaira T,Gow RV,Kelly J,et al.Biochemical and psychological effects of omega-3/6 supplements in male adolescents with attention-deficit/hyperactivity disorder:a randomized,placebo-controlled,clinical trial[J].J Child Adolesc Psychopharmacol,2015,25(10):775-782.
[19] Cooper RE,Tye C,Kuntsi J,et al.Omega-3 polyunsaturated fatty acid supplementation and cognition:a systematic review and meta-analysis[J].J Psychopharmacol,2015,29(7):753-763.
[20] Cooper RE,Tye C,Kuntsi J,et al.The effect of omega-3 polyunsaturated fatty acid supplementation on emotional dysregulation,oppositional behaviour and conduct problems in ADHD:a systematic review and meta-analysis[J].J Affect Disord,2016,190:474-482.
[21] Cinque S,Zoratto F,Poleggi A,et al.Behavioral phenotyping of dopamine transporter knockout rats:compulsive traits,motor stereotypies,and anhedonia[J].Front Psychiatry,2018,9:43.
[22] Villagomez A,Ramtekkar U.Iron,magnesium,vitamin D,and zinc deficiencies in children presenting with symptoms of attention-deficit/hyperactivity disorder[J].Children (Basel),2014,1(3):261-279.
[23] Hariri M,Azadbakht L.Magnesium,iron,and zinc supplementation for the treatment of attention deficit hyperactivity disorder:a systematic review on the recent literature[J].Int J Prev Med,2015,6:83.
[24] Prasad AS,Bao B.Molecular mechanisms of zinc as a pro-antioxidant mediator:clinical therapeutic implications[J].Antioixdants (Basel),2019,8(6):E164.
[25] Mahmoud MM,El-Mazary AA,Maher RM,et al.Zinc,ferritin,magnesium and copper in a group of Egyptian children with attention deficit hyperactivity disorder[J].Ital J Pediatr,2011,37:60.
[26] Scassellati C,Bonvicini C,Faraone SV,et al.Biomarkers and attention-deficit/hyperactivity disorder:a systematic review and meta-analyses[J].J Am Acad Child Adolesc Psychiatry,2012,51(10):1003-1019.
[27] Zhou F,Wu F,Zou S,et al.Dietary,nutrient patterns and blood essential elements in Chinese children with ADHD[J].Nutrients,2016,8(6):E352.
[28] Bilici M,Ylldrlm F,Kandil S,et al.Double-blind,placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder[J].Prog Neuropsychopharmacol Biol Psychiatry,2004,28(1):181-190.
[29] Akhondzadeh S,Mohammadi MR,Khademi M.Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children:A double blind and randomized trial[ISRCTN64132371][J].BMC Psychiatry,2004,4:9.
[30] Zamora J,Velásquez A,Troncoso L,et al.Zinc in the therapy of the attention-deficit/ hyperactivity disorder in children.A preliminar randomized controlled trial[J].Arch Latinoam Nutr,2011,61(3):242-246.
[31] Lange KW,Hauser J,Lange KM,et al.Therole of nutritional supplements in the treatment of ADHD:what the evidence says[J].Curr Psychiatry Rep,2017,19(2):8.
[32] Gold MS,Blum K,Oscar-Berman M,et al.Low dopamine function in attention deficit/hyperactivity disorder:should genotyping signify early diagnosis in children?[J].Postgard Med,2014,126(1):153-177.
[33] Bener A,Kamal M,Bener H,et al.Higher prevalence of iron deficiency as strong predictor attention deficit hyperactivity disorderin children[J].Ann Med Health Sci Res,2014,4(Suppl 3):291-297.
[34] Konofal E,Lecendreux M,Deron J,et al.Effects of iron supplementation on attention deficit hyperactivity disorder in children[J].Pediatr Neurol,2008,38(1):20-26.
[35] Li X,Allen RP,Earley CJ,et al.Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla[J].Sleep Med,2016,22:75-82.
[36] 施卫萍,季加忠.营养性缺铁性贫血与注意缺陷多动障碍的临床关系研究-258例病例分析[J].现代生物医学进展,2007,7(12):1863-1865.
[37] Adisetiyo V,Helpern JA.Brain iron:a promising noninvasive biomarker of attention-deficit/hyperactivity disorder that warrants further investigation[J].Biomark Med,2015,9(5):403-406.
[38] Huang YH,Zeng BY,Li DJ,et al.Significantly lower serum and hair magnesium levels in children with attention deficit hyperactivity disorder than controls:a systematic review and meta-analysis[J].Prog Neuropsychopharmacol Biol Psychiatry,2019,90:134-141.
[39] Mousain-Bosc M,Roche M,Polge A,et al.Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6.I.Attention deficit hyperactivity disorders[J].Magnes Res,2006,19(1):46-52.
[40] El Baza F,Alshahawi HA,Zahra S,et al.Magnesium supplementation in children with attention deficit hyperactivity disorder[J].Egypt J Med Hum Genet,2016,17(1):63-70.
[41] Ghanizadeh A.A systematic review of magnesium therapy for treating attention deficit hyperactivity disorder[J].Arch Iran Med,2013,16(7):412-417.