Analysis of serum 25-hydroxy vitamin-D level and children's growth pain and other related factors

doi:10.11852/zgetbjzz2019-1297

Abstract

Abstract: Objective To investigate the serum 25-hydroxy vitamin D[25-(OH)D] level and other related factors of children's growth pain (growing pain,GP). Methods From December 2015 to June 2019,121 children with GP inDaxing District Maternal and Child Health Hospital were treated as the observation group,and 121 healthy children who came to our hospital for physical examination during the period were selected as the control group.Observation group was given comprehensive treatment such as vitamin D supplementation to observe the curative effect and compare the changes of serum 25-(OH)D,blood calcium,blood phosphorus and bone mineral density of children before and after treatment.Univariate and multivariate analysis of other risk factors for GP may occur. Results A total of 105 cases were effective,the effective rate was 86.78%; 25-(OH)D was significantly higher than before treatment (P<0.01),close to the control group,no statistical significance compared with the control group (P>0.05); Blood calcium and blood phosphorus levels before and after treatment compared with ultrasound bone mineral density,the difference was not statistically significant (P>0.05),and compared with the control group was not statistically significant (P>0.05); Logistic regression test showed that family history(OR＝2.116,95%CI:1.653~2.879),physical activity time>2 h/d(OR＝1.279,95%CI:1.038~1.508),and picky eating (OR＝2.745,95%CI:1.348~5.607)were all risk factors for GP. Conclusions Children's GP may be related to 25-(OH)D levels.Vitamin D has a significant therapeutic effect on GP(P<0.05 or <0.01).The children's bone nutritional status is evaluated and effective treatments are formulated.

Key words: 25-(OH)D, serum, growing pain, children

摘要： 目的分析血清25羟维生素D[25-(OH)D]水平及发生儿童生长痛(GP)及其它相关因素,为临床干预提供理论依据。方法 2015年12月-2019年6月以北京市大兴区妇幼保健院收治的121例儿童GP患儿作为观察组,选取同期来本院体检的健康儿童121例作为对照组。观察组给予补充维生素D等综合治疗,观察疗效,并对比治疗前后儿童血清25-(OH)D、血钙、血磷及骨密度水平变化,并对可能发生GP的其他危险因素进行单因素、多因素分析。结果 121例患儿经治疗后,有效105例,有效率为86.78%。25-(OH)D水平明显高于治疗前(P＜0.01),接近对照组,与对照组比较差异无统计学意义(P＞0.05);治疗前后血钙、血磷水平、超声骨密度比较,差异均无统计学意义(P＞0.05),与对照组比较差异均无统计学意义(P＞0.05);Logistic回归检验显示有家族史(OR＝2.116,95%CI:1.653~2.879)、体育活动时间>2 h/d(OR＝1.279,95%CI:1.038~1.508)、挑食(OR＝2.745,95%CI:1.348~5.607)均是GP发生的危险因素(P<0.05或<0.01)。结论儿童GP可能与25-(OH)D水平有关,维生素D对于GP的治疗效果显著,对患儿骨营养状态进行评估并对其制定有效的治疗方案。

关键词: 25-羟维生素D, 血清, 生长痛, 儿童

CLC Number:

R179

LI Xue-feng. Analysis of serum 25-hydroxy vitamin-D level and children's growth pain and other related factors[J]. journal1, 2021, 29(2): 194-197.

李雪峰. 儿童生长痛与血清25羟维生素D水平及其它相关因素分析[J]. 中国儿童保健杂志, 2021, 29(2): 194-197.

References

[1] Espinha T,Zaidman A,Gross HG.Web API growing pains:Loosely coupled yet strongly tied[J].J Syst Softw,2015,12(100):27-43.
[2] 蒋艳琼,庄桂英,李思涛,等.不同胎龄早产儿血清25羟维生素D水平及其与骨定量超声值的关系[J].中华实用儿科临床杂志,2016,31(19):1468-1470.
[3] 侯佳彤,潘慧,朱惠娟.儿童青少年过度生长的临床诊疗进展[J].中华实用儿科临床杂志,2016,31(4):316-318.
[4] 中华医学会儿科学分会儿童保健学组,《中华儿科杂志》编辑委员会.儿童微量营养素缺乏防治建议[J].中华儿科杂志,2010,48(7):502-509.
[5] 李范玲,张惠佳,李欣,等.135名学龄前生长痛儿童压痛阈研究[J].中国儿童保健杂志,2016,24(1):22-25.
[6] Morandi G,Maines E,Piona C,et al.Significant association among growing pains,vitamin D supplementation,and bone mineral status:results from a pilot cohort study[J].J Bone Miner Metab,2015,33(2):201-206.
[7] Gr&Xe KA.Power and priorities:the growing pains of global health:comment on "knowledge,moral claims and the exercise of power in global health"[J].Int J Health Policy Manag,2015,4(5):321-322.
[8] 李欣.儿童生长痛的流行病学调查及与相关因素的分析[D].北京:中国人民解放军总医院;解放军医学院,2016:1-89.
[9] 白磊.儿童生长痛临床研究[J].云南医药,2016,16(5):489-491.
[10] 陈小香,谭新,邓伟民.骨质疏松症患者骨密度与血清25羟维生素D的相关性研究[J].中国骨质疏松杂志,2017,23(7):851-855.
[11] 田越,吴海霞.极低出生体重早产儿血清磷、骨碱性磷酸酶、25-羟基维生素D水平动态变化分析[J].中华流行病学杂志,2015,36(11):1288-1290.
[12] 夏黎,崔县伟,王玉,等.南京地区0~5岁儿童25-羟基维生素D水平及其与季节的关系[J].中华实用儿科临床杂志,2015,30(19):1470-1472.
[13] 王强,周翔,李慧丽.龙岗区1～12岁儿童血清25-羟维生素D检测结果分析[J].临床儿科杂志,2015,12(6):570-570.
[14] 田谧,李远,王燕,等.重庆市永川区3～6岁留守儿童25-羟维生素D水平及其与维生素D受体基因FOKⅠ位点多态性的相关性研究[J].第三军医大学学报,2017,39(5):493-498.
[15] 李毅中,庄华烽,郭良瑞,等.骨密度和25羟维生素D在骨质疏松性髋部骨折的作用[J].中国骨质疏松杂志,2015,21(12):1457-1459.
[16] 上官莉莉,赵亚茹.注意缺陷多动障碍患儿血清25羟基维生素D水平的检测[J].中国当代儿科杂志,2015,17(8):837-840.
[17] Kaspiris A,Zafiropoulou C.Growing pains in children:epidemiological analysis in a Mediterranean population[J].Joint Bone Spine,2009,76(5):486-490.
[18] Champion D,Pathirana S,Flynn C,et al.Growing pains:Twin family study evidence for genetic susceptibility and a genetic relationship with restless legs syndrome[J].Eur J Pain,2012,16(9):1224-1231.