Abstract: Objective To explore the correlation between intercellular adhesion factor-1 (ICAM-1) and asthma severity,airway inflammation response in children,in order to provide scientific reference for early diagnosis and assessment of asthma. Methods The clinical data of 80 children with asthma admitted to Nanyang Central Hospital from August 2018 to July 2020 were retrospectively analyzed. According to different severity levels,children were divided into mild,moderate and severe asthma groups. And 80 healthy children who underwent physical examination in the hospital during the same period were enrolled as control group. The changes of ICAM-1 level in sputum of all groups were explored. The correlation between ICAM-1 and asthma severity,airway inflammation response was analyzed. Results The levels of sputum ICAM-1,interleukin-6 (IL-6),IL-13 and tumor necrosis factor (TNF-α) in asthma group were significantly higher than those in normal group (t＝40.251,27.532,48.393,23.096,P<0.05). The differences in levels of sputum ICAM-1,IL-6,IL-13 and TNF-α,as well as lung function indexes [vital capacity (VC),forced expiratory volume in the first second (FEV1),peak expiratory flow (PEF)] were statistically significant among children with different asthma severity levels (F=16.410,38.726,12.167,46.661,29.540,10.419,24.676,P<0.05). The levels of sputum ICAM-1,IL-6,IL-13 and TNF-α in severe asthma group were higher than those in mild and moderate asthma groups. FEV1,VC and PEF in severe and moderate asthma groups were lower than those in mild asthma group (P<0.05). Spearman correlation analysis showed that the level of sputum ICAM-1 was positively correlated with IL-6,IL-13,TNF-α and asthma severity (r=0.745,0.684,0.786,0.692,P<0.05),while negatively correlated with FEV1,VC and PEF (r=-0.457,-0.378,-0.692,P<0.05). Conclusions The level of sputum ICAM-1 in asthma children is higher than that in healthy children. Detecting the level of sputum ICAM-1 is of certain practical value in assessing disease severity and airway inflammation response.

Key words: intercellular adhesion factor-1, asthma, inflammatory response, children

摘要： 目的 分析细胞间黏附因子(ICAM-1)与儿童哮喘严重程度及气道炎症反应相关性,为儿童哮喘的早期诊断和病情评估提供科学依据。方法 回顾性分析2018年8月—2020年7月南阳市中心医院收治80例哮喘患儿的临床资料,根据哮喘严重程度将患儿分为轻度、中度及重度哮喘组,并选取同期在医院进行体检的健康儿童80例作为对照组,讨论各组儿童痰液ICAM-1水平的变化,分析ICAM-1与哮喘严重程度及气道炎症反应相关性。结果 哮喘组痰液ICAM-1、白细胞介素(IL)-6、IL-13、肿瘤坏死因子(TNF-α)水平均高于正常组(t=40.251、27.532、48.392、23.096,P＜0.05)。不同哮喘严重程度患儿的痰液ICAM-1、IL-6、IL-13、TNF-α水平以及肺功能指标中肺活量(VC)、第1秒用力呼气量(FEV1)、呼气峰值流速(PEF)比较,差异均有统计学意义(F=16.410、38.726、12.167、46.661、29.540、10.419、24.676,P＜0.05);其中,重度哮喘患儿痰液ICAM-1、IL-6、IL-13、TNF-α水平均高于轻度组、中度组;重度、中度哮喘患儿FEV1、VC、PEF均低于轻度组(P＜0.05)。Spearman相关性分析结果显示,哮喘患儿痰液ICAM-1水平与IL-6、IL-13、TNF-α水平、哮喘严重程度均呈正相关(r=0.745、0.684、0.786、0、692,P＜0.05);哮喘患儿痰液ICAM-1水平与FEV1、VC、PEF呈负相关(r=-0.457、-0.378、-0.692,P＜0.05)。结论 哮喘患儿痰液ICAM-1水平高于健康儿童,其水平与哮喘严重程度分级、IL-6、IL-13、TNF-α水平呈正相关,与肺功能指标呈负相关。检测哮喘患儿痰液ICAM-1水平,在评估其疾病严重程度、气道炎症反应中有一定实用价值。

关键词: 细胞间黏附因子, 哮喘, 炎症反应, 儿童