Effects of maternal dietary nutrition during pregnancy on obesity and  metabolism in children

doi:10.11852/zgetbjzz2021-0952

Abstract

Abstract: Childhood obesity is a global public health problem, and its causes are closely related to exposure to adverse environments in early life. Dietary nutrition during pregnancy can affect the intrauterine environment of the fetus, which has an important influence on the morbidity of obesity and metabolic diseases in the offspring. This review focuses on the existing research evidence on the association of the energy intake, various dietary nutrients intake and the dietary patterns during pregnancy with childhood obesity and metabolic diseases, summarizes the effects of dietary nutrition during pregnancy on the metabolism of offspring, and put forward suggestions on rational dietary intake during pregnancy, so as to provide reference for the prevention and control of obesity and metabolic diseases in early life.

Key words: pregnancy, energy intake, nutrient, dietary pattern, child obesity

摘要： 儿童肥胖是一个全球性的公共卫生问题,其发病原因与生命早期暴露及不良环境密切相关。孕期膳食营养影响着胎儿的宫内环境,进而对子代肥胖与代谢疾病的发病产生重要影响。本文对孕期能量摄入水平、各类膳食营养素摄入情况以及孕期膳食模式与儿童肥胖和代谢疾病发病关联的现有研究证据进行综述,总结孕期膳食营养对子代代谢的作用,对孕期合理膳食摄入提出建议,为生命早期防控肥胖及代谢病提供参考。

关键词: 孕期, 能量摄入, 营养素, 膳食模式, 儿童肥胖

CLC Number:

WAN Ning-yu, HU Jia-jin, LIU Yang, MA Ya-nan, WEN De-liang. Effects of maternal dietary nutrition during pregnancy on obesity and metabolism in children[J]. Chinese Journal of Child Health Care, 2022, 30(1): 44-48.

万宁钰, 胡嘉晋, 刘洋, 马亚楠, 闻德亮. 母亲孕期膳食营养对儿童肥胖与代谢的影响[J]. 中国儿童保健杂志, 2022, 30(1): 44-48.

References

[1] 廖月园, 牟建军. BMI的长期负担对远期心脏代谢表型的影响:30年的队列随访研究[J]. 中国妇幼健康研究,2021, 32(6):787-792.
[2] Alvina RK,Sinduja L,Jay MS.Childhood and adolescent obesity:A review[J].Front Pediat, 2021,8:581461.
[3] 马冠生, 张曼. 儿童肥胖的防控,应从生命早期开展[J].中国妇幼健康研究,2021, 32(6):782-786.
[4] 曾果. 中国营养学会“孕期妇女膳食指南(2016)”解读[J].实用妇产科杂志,2018, 34(4):265-267.
[5] Ukah UV, Bayrampour H, Sabr Y, et al. Association between gestational weight gain and severe adverse birth outcomes in Washington State, US:A population-based retrospective cohort study, 2004-2013[J]. PLoS Med, 2019, 16(12):e1003009.
[6] Goldstein RF, Abell SK, Sanjeeva R, et al. Gestational weight gain across continents and ethnicity: Systematic review and meta-analysis of maternal and infant outcomes in more than one million women[J]. 2018, 16(1):1-14.
[7] Blumfield ML, Schreurs M, Rollo ME, et al. The association between portion size, nutrient intake and gestational weight gain:A secondary analysis in the WATCH study 2006/7[J]. J Hum Nutr Diet, 2016, 29(3):271-280.
[8] Wang Y, Ma H, Feng Y, et al. Association among pre-pregnancy body mass index, gestational weight gain and neonatal birth weight:A prospective cohort study in China[J]. BMC Pregnancy Childbirth,2020, 20(1):690.
[9] Josey MJ, McCullough LE, Hoyo C, et al. Overall gestational weight gain mediates the relationship between maternal and child obesity[J]. BMC Public Health, 2019, 19(1):1062.
[10] Hu J, Aris IM, Oken E, et al. Association of total and trimester-specific gestational weight gain rate with early infancy weight status:A prospective birth cohort study in China[J]. Nutrients, 2019, 11(2):280.
[11] Karachaliou M, Georgiou V, Roumeliotaki T, et al. Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood[J]. Am J Obstet Gynecol,2015, 212(4):502.
[12] Torres C, Schultz LF, Veugelers PJ, et al. The effect of pre-pregnancy weight and gestational weight gain on blood pressure in children at 6 years of age[J]. J Public Health (Oxf),2020, 43(2):e161-e170.
[13] Nijs H, Benhalima K. Gestational diabetes mellitus and the long-term risk for glucose intolerance and overweight in the offspring:A narrative review[J]. J Clin Med, 2020, 9(2):599.
[14] Pedersen J. Weight and length at birth of infants of diabetic mothers[J]. Acta Endocrinol (Copenh), 1954, 16(4):330-342.
[15] Qin LL, Luo BA, Gao F, et al. Effect of exposure to famine during early life on risk of metabolic syndrome in adulthood: a meta-analysis[J]. J Diabetes Res, 2020, 2020(4):1-9.
[16] Na L, Wei W, Wu G, et al. Nutritional support for low birth weight infants:Insights from animal studies[J]. Br J Nutr, 2017, 117(10):1390-1402.
[17] Mousa A, Naqash A, Lim S. Macronutrient and micronutrient intake during pregnancy: an overview of recent evidence[J]. Nutrients, 2019, 11(2):443.
[18] Koski KG, Hill FW. Effect of low carbohydrate diets during pregnancy on parturition and postnatal survival of the newborn rat pup[J]. J Nutr, 1986, 116(10):1938-1948.
[19] Brei C, Stecher L, Meyer DM, et al. Impact of dietary macronutrient intake during early and late gestation on offspring body composition at birth, 1, 3, and 5 years of age[J]. Nutrients, 2018, 10(5):579.
[20] Cecelia O, Jennie L, Andrea D, et al. In overweight or obese pregnant women, maternal dietary factors are not associated with fetal growth and adiposity[J]. Nutrients, 2018, 10(7):870.
[21] Renault KM, Carlsen EM, Kirsten N, et al. Intake of carbohydrates during pregnancy in obese women is associated with fat mass in the newborn offspring[J]. Am J Clin Nutr, 2015, 102(6):1475-1481.
[22] Elango R, Ball RO. Protein and amino acid requirements during pregnancy[J]. Adv Nutr, 2016, 7(Suppl4):839-844.
[23] Halldorsson TI, Birgisdottir B, Brantster AL, et al. Old question revisited:Are high-protein diets safe in pregnancy?[J]. Nutrients, 2021, 13(2):440.
[24] Stevens B,Buettner P, Watt K, et al. The effect of balanced protein energy supplementation in undernourished pregnant women and child physical growth in low- and middle-income countries:A systematic review and meta-analysis[J]. Matern Child Nutr, 2015, 11(4):415-432.
[25] Grobler L, Visser M, Siegfried NJOR. Healthy life trajectories initiative: summary of the evidence base for pregnancy-related interventions to prevent overweight and obesity in children[J]. Obes Rev, 2019, 20(Suppl1):18-30.
[26] Allman BR, Andres A,Børsheim E. The association of maternal protein intake during pregnancy in humans with maternal and offspring insulin sensitivity measures[J]. Curr Dev Nutr, 2019, 3(6):nzz055.
[27] Allman BR, Williams DK, Bøsheim E, et al. Dietary protein intake during pregnancy is not associated with offspring insulin sensitivity during the first two years of life[J]. Nutrients, 2020, 12(5):1338.
[28] Pang WW, Colega M, Cai S, et al. Higher maternal dietary protein intake is associated with a higher risk of gestational diabetes mellitus in a multiethnic Asian cohort[J]. J Nutr, 2017, 147(4):653-660.
[29] Shiell AW, Campbell DM, Hall MH, et al. Diet in late pregnancy and glucose-insulin metabolism of the offspring 40 years later[J]. Bjog, 2000, 107(7):890.
[30] Caut C, Leach M, Steel AJM, et al. Dietary guideline adherence during preconception and pregnancy:A systematic review[J]. Matern Child Nutr, 2020, 16(2):e12916.
[31] Mennitti LV, Oliveira JL, Morais CA, et al. Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring[J]. J Nutr Biochem, 2015, 26(2):99-111.
[32] Wang Z, Zou Z, Wang S, et al. Chinese famine exposure in infancy and metabolic syndrome in adulthood:Results from the China health and retirement longitudinal study[J]. Eur J Clin Nutr, 2019, 73(5):724-732.
[33] Vinding RK, Stokholm J, Sevelsted A, et al. Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years:Randomised clinical trial[J]. BMJ, 2018, 362:k3312.
[34] Kerling EH, Hilton JM, Thodosoff JM, et al. Effect of prenatal docosahexaenoic acid supplementation on blood pressure in children with overweight condition or obesity:A secondary analysis of a randomized clinical Trial[J]. JAMA Intern Med, 2019, 2(2):930-938.
[35] Ren X, Vilhjálmsdóttir BL, Rohde JF, et al. Systematic literature review and meta-analysis of the relationship between polyunsaturated and trans fatty acids during pregnancy and offspring weight development[J]. Front Nutr, 2021, 8:625596.
[36] Oh C, Keats EC, Bhutta ZA. Vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries:A systematic review and meta-analysis[J]. Nutrients, 2020, 12(2):491.
[37] Aya M,Amreen N,Siew L. Macronutrient and micronutrient intake during pregnancy:An overview of recent evidence[J]. Nutrients, 2019, 11(2):443.
[38] Rogne T, Tielemans MJ, Chong MF, et al. Associations of maternal vitamin B12 concentration in pregnancy with the risks of preterm birth and low birth weight:A systematic review and meta-analysis of individual participant data[J]. Am J Epidemiol, 2017, 185(3):212-223.
[39] Sukumar N, Rafnsson SB. Prevalence of vitamin B12 insufficiency during pregnancy and its effect on offspring birth weight:A systematic review and meta-analysis[J]. Am J Clin Nutr, 2016, 103(5):1232-1251.
[40] Darlow BA, Martin J, Horwood LJ. Metabolic syndrome in very low birth weight young adults and controls:The new Zealand 1986 VLBW study[J]. J Pediatr, 2019, 206:128-133.
[41] Yajnik CS, Deshpande SS, Jackson AA, et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring:The Pune maternal nutrition study[J]. Diabetologia, 2008, 51(1):29-38.
[42] Crozier SR, Harvey NC, Inskip HM, et al. Maternal vitamin D status in pregnancy is associated with adiposity in the offspring:Findings from the Southampton Women's Survey[J]. Am J Clin Nutr, 2012, 96(1):57-63.
[43] Santamaria C, Wei GB, Leduc L, et al. Prenatal vitamin D status and offspring's growth, adiposity and metabolic health:A systematic review and meta-analysis[J]. Br J Nutr, 2018, 119(3):1-10.
[44] Cohen JM, Kahn SR, Platt RW, et al. Small-for-gestational-age birth and maternal plasma antioxidant levels in mid-gestation:A nested case-control study[J]. Bjog, 2015, 122(10):1313-1321.
[45] Gebremedhin S, Enquselassie F, Umeta MJPO. Independent and joint effects of prenatal zinc and vitamin a deficiencies on birthweight in rural sidama, Southern Ethiopia:prospective cohort study[J]. PLoS One, 2012, 7(12):e50213.
[46] Biagi C, Nunzio M, Bordoni A, et al. Effect of adherence to mediterranean diet during pregnancy on children's health:A systematic review[J]. Nutrients, 2019, 11(5):997.
[47] Chatzi L, Rifas-Shiman SL, Georgiou V, et al. Adherence to the mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood[J]. Pediatr Obes, 2017, 12 (Suppl 1):47-56.
[48] Liu D, Cheng Y, Mi B, et al. Maternal dietary patterns during pregnancy derived by reduced-rank regression and birth weight in the Chinese population[J]. Br J Nutr, 2020, 123(10):1176-1186.
[49] Hu J, Aris I, Lin PI, et al. Association of maternal dietary patterns during pregnancy and offspring weight status across infancy:Results from a prospective birth cohort in China[J]. Nutrients, 2021, 13(6):2040.
[50] Chen LW, Aris IM, Bernard JY, et al. Associations of maternal dietary patterns during pregnancy with offspring adiposity from birth until 54 months of age[J]. Nutrients, 2017, 9(1):2.

Effects of maternal dietary nutrition during pregnancy on obesity and metabolism in children

母亲孕期膳食营养对儿童肥胖与代谢的影响

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