Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (10): 1132-1135.DOI: 10.11852/zgetbjzz2021-1443

• Clinical Research • Previous Articles     Next Articles

Relationship between recurrent wheezing and gene prediction model of four-locus asthma in children and risk factors of recurrent wheezing

SHEN Ren, YANG Shan-pu, ZHANG Lin-tao, WU Yue-chao   

  1. Department of Pediatrics, Yuhuan People's Hospital of Zhejiang Province, Yuhuan, Zhejiang 317600, China
  • Received:2021-09-21 Revised:2021-12-10 Online:2022-10-10 Published:2022-10-14
  • Contact: YANG Shan-pu,


沈仁, 杨善浦, 张林桃, 吴月超   

  1. 玉环市人民医院儿科,浙江 玉环 317600
  • 通讯作者: 杨善浦,
  • 作者简介:沈仁(1984-),男,浙江人,副主任医师,医学硕士,主要从事小儿呼吸系统疾病研究。
  • 基金资助:

Abstract: Objective To explore the relationship between recurrent wheezing and gene prediction model of four-locus asthma in children, and to analyze the risk factors of recurrent wheezing. Methods A total of 91 asthmatic children who were hospitalized or saw a doctor in outpatient clinics in Yuhuan People's Hospital from January 2019 to March 2021 were selected into this study. According to the asthma predictive index(API) result, children were divided into API positive group(n=55) and API negative group(n=36).Meanwhile, 30 healthy children were selected as the control group. The high-risk rates of four-locus asthma gene prediction model among three groups were compared. The influencing factors of recurrent wheezing were analyzed by univariate and multivariate Logistic regression. Results The high-risk rate of four-locus asthma gene prediction model in API positive group was significantly higher than that in API negative group and control group(χ2 =12.487, P<0.05). The risk of the four-locus asthma gene prediction model in the API positive group was 2.54 times higher than that in the API negative group and 5.32 times higher than that in the control group. Univariate analysis indicated that children's recurrent wheezing was associated with high risk type of the four-locus asthma gene prediction model, allergy history, family history of allergic diseases, positive inhaled allergens, positive ingested allergens, passive smoking, elevated eosinophil count and respiratory syncytial virus infection(χ2=13.831, 22.817, 25.475, 20.573, 6.373, 11.487, 10.790, 10.789, P<0.05), but not related to living surroundings(P>0.05). Multivariate Logistic regression analysis showed that the high risk type of four-locus asthma gene prediction model(OR=5.535, 95%CI: 1.928 -15.893), allergy history(OR=4.921, 95%CI:1.661 - 14.577), family history of allergic diseases(OR=4.460, 95%CI:1.560 - 12.749),positive inhaled allergens(OR=13.105, 95%CI:2.436 - 70.503) and passive smoking(OR=3.704, 95%CI:1.304 - 10.521) were independent risk factors for recurrent wheezing. Conclusions The high risk rate of four-locus asthma gene prediction model is significantly increased in children with recurrent wheezing, especially API positive children. Repeated wheezing is caused by multiple factors, among which the high risk type of four-locus asthma gene prediction model is an important reason.

Key words: wheezing, asthma predictive index, gene, asthma, children

摘要: 目的 探讨儿童反复喘息与4位点哮喘基因预测模型的关系,分析反复喘息的危险因素。方法 选取2019年1月—2021年3月在玉环市人民医院住院或门诊就诊的喘息儿童91例,根据哮喘预测指数(API)是否阳性,分为API阳性组55例,API阴性组36例,同时选择健康体检儿童30例为对照组。比较3组儿童4位点哮喘基因预测模型的高危率;将反复喘息儿童进行单因素及多因素Logistic回归分析。结果 API阳性组4位点哮喘基因预测模型的高危率较API阴性组及对照组显著升高(χ2=12.487,P<0.05);API阳性组4位点哮喘基因预测模型的高危风险是API阴性组的2.54倍,是对照组的5.32倍。单因素分析儿童反复喘息与4位点哮喘基因预测模型的高危型、过敏史、过敏疾病家族史、吸入过敏原阳性、食入过敏原阳性、被动吸烟、嗜酸性粒细胞计数升高及呼吸道合胞病毒感染等因素有关(χ2=13.831,22.817,25.475,20.573,6.373,11.487,10.790,10.789,P<0.05),而与居住环境无关(P>0.05)。多因素Logistic回归分析显示4位点哮喘基因预测模型的高危型(OR=5.535,95%CI:1.928~15.893)、过敏史(OR=4.921,95%CI:1.661~14.577)、过敏疾病家族史(OR=4.460,95%CI:1.560~12.749)、吸入过敏原阳性(OR=13.105,95%CI:2.436~70.503)、被动吸烟(OR=3.704,95%CI:1.304~10.521)为喘息的独立危险因素。结论 反复喘息儿童,尤其是API阳性儿童,4位点哮喘基因预测模型的高危率显著升高;反复喘息与多种因素有关,其中4位点哮喘基因预测模型高危型是一个重要原因。

关键词: 喘息, 哮喘预测指数, 基因, 哮喘, 儿童

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