Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (11): 1208-1211.DOI: 10.11852/zgetbjzz2021-0483

Special Issue: 孤独症谱系障碍

• Review • Previous Articles     Next Articles

Influencing factors of developmental regression in children with autism spectrum disorder

ZHOU Ping, CHEN Li   

  1. Growth, Development and Mental Health Center for Children and Adolescents, Children's Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Translational; Chongqing Key Laboratory of Child Nutrition and Health, Chongqing 400014, China
  • Received:2021-04-01 Revised:2021-05-13 Online:2022-11-10 Published:2022-11-09
  • Contact: CHEN Li,


周平, 陈立   

  1. 重庆医科大学附属儿童医院儿童青少年生长发育与心理健康中心/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/认知发育与学习记忆障碍转化医学重庆市重点实验室/儿童营养与健康重庆市重点实验室,重庆 400014
  • 通讯作者: 陈立,
  • 作者简介::周平(1993- ),女,重庆人,住院医师,在读硕士研究生,主要研究方向为儿童发育障碍性疾病。
  • 基金资助:

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized as heterogeneous clinical manifestations.Developmental regression, regarded as a specific subtype in ASD, is getting more and more attention.However, the influencing factors of regression are not clear.It is generally believed that it is a kind of developmental disorder caused by genetics, environment and their interaction.This review aims to summarize the influencing factors increasing risk of regressive autism from the perspective of environment and genetics, thereby providing references for the recognition and interventions in early childhood.

Key words: autism spectrum disorder(ASD), developmental regression, neurodevelopmental disorder

摘要: 孤独症谱系障碍(ASD)是一组以不同临床表现为主要特征的神经发育性障碍。近年来,ASD儿童的发育倒退(DR)受到越来越多的关注,并被认为可能是ASD的一种特殊亚型。目前关于ASD儿童DR的影响因素尚不清楚,综合文献分析主要是由遗传、环境及其交互作用共同引起。本文拟从遗传和环境两方面对目前报道的ASD儿童DR影响因素进行总结,为该部分ASD患儿的临床早期识别和干预提供参考。

关键词: 孤独症谱系障碍, 发育倒退, 神经发育性障碍

CLC Number: