Abstract: AIM: To evaluate the efficacy and safety of flurbiprofen axetil pretreatment in preventing post-anesthetic hyperalgesia induced by remifentanil.METHODS: 80 patients scheduled for gynecological laproscopic surgery were recruited and randomly allocated into four groups, each group had 20 cases. In group Ⅰ(small dose RF group), remifentanil was administered 0.1 μg·kg^-1·min^-1 during operation. In group Ⅱ(large dose RF group), remifentanil was administered 0.4 μg·kg^-1·min^-1 during operation. While in group Ⅲ(small dose RF+F group) flurbiprofen axetil 1.5 mg/kg was injected before induction of anesthesia, remifentanil was administered 0.1 μg·kg^-1·min^-1 perioperatively, in group Ⅳ(large dose RF+F group) flurbiprofen axetil 1 mg/kg was injected before induction of anesthesia, and remifentanil was administered 0.4 μg·kg^-1·min^-1 perioperatively. Time of spontaneous respiration, recovery of consciousness and endotracheal extubation were recorded. Pain levels during post-anesthetic recovery period were observed and number of times of salvage fentanyl after extubation were compared.RESULTS: There were no statistical significance in spontaneous respiration recovery, recovery of consciousness and extubation in four groups(P>0.05).Pain score in large RF group was higher and times of salvage fentanyl was more when compared to that in small RF group(P<0.05). Pain score and salvage fentanyl were decreased in groups of which flurbiprofen axetil administered in advance.CONCLUSION: Perioperative large dose remifentanil administration might induce postoperative hyperalgesia, while flurbiprofen axetil to some extent could prevent hyperalgesia induced by remifentanil and has no effect on patients' recovery.

Key words: Flurbiprofen axetil , Remifentanil , Preemptive analgesia, Hyperalgesia