Abstract: AIM: To investigate the efftct of Gypenosides on contraction of isolated duodenum smooth mustle of rabbits. METHODS: The routine experimental method of isolated duodenal smooth muscle of rabbits were used. The contraction curves of isolated duodenum smooth mustle before and after administration of different concentrations of Gypenosides (0.01%-1.00%) were recorded by Medlab biological information collecting system. RESULTS: Different concentrations of Gypenosides significantly reduced thecontraction amplitude of isolated duodenum smooth mustle of rabbits, and showed a dose -dependent relationship. CONCLUSION: Gypenosides can inhibit the contraction of isolated duodenum smooth muscle of rabbits.

Key words: Gypenosides, isolated duodenum, contract