Role of Nrf2 in neuroprotection and its mechanisms

Abstract

Abstract: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor, which sensitive to the oxidative stress and electrophiles, translocation to nucleus after dissociation with Keap1, induce expression of a variety of cytoprotective and detoxification genes. Several of the genes which regulated by Nrf2 have been illustrated in prevention from neurodegenerative conditions. Work from several laboratories has implicated the potential for Nrf2-mediated transcription to protect conditions such as hypoxia, ischemic-reperfusion,Alzhemier's disease, Parkinson's disease and Amyotrophic lateral sclerosis, resulting from mechanisms involving oxidative stress. Nrf2 may be notable in fighting conditions with variable causes and etiologies. Therefore, we review the current literature that imply Nrf2 may be a crucial therapeutic target for neuronal system disease, as well as experiments that uncover potential mechanisms of protection.

Key words: Oxidative stress, Nrf2, Neuroprotection, Keap1, Antioxidant-responsive element

CLC Number:

CAO Shan, ZHOU Gan, PENG Xiang-dong, YANG Guo-ping, ZHOU Hong-hao. Role of Nrf2 in neuroprotection and its mechanisms[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(6): 696-704.

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