Research advances in Sirt1 regulating microRNA

Abstract

Abstract: Sirt1 is a member of silent information regulator (Sir2) family, which is a class III histone NAD+ - dependent deacetylase playing a pivotal role in the cell survival,apoptosis, tumor development, metabolic diseases and anti-aging.MicroRNA (miRNA) is a short,no encoding,single-stranded RNA that exists in eukaryotic organisms. Recent studies show that miRNA can regulate the expression of Sirt1 at the post-transcriptional level. Therefore, miRNA may become a new target in the treatment of many diseases, which has been the focus of researchers.

Key words: Sirt1, miRNA

CLC Number:

R965.2

WAN Jing-zhi, YUAN Ding, WANG Ting. Research advances in Sirt1 regulating microRNA[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1430-1435.

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