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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 339-340.

• 临床研究 • 上一篇    下一篇

盐酸丁咯地尔注射液治疗糖尿病性周围神经病变的疗效评价

张领, 介小霞, 王素琴1   

  1. 河南省平顶山市第二人民医院干部病房, 平顶山 467000;
    1河南省平顶山市医药集团, 平顶山 467000
  • 收稿日期:2002-03-05 修回日期:2002-05-01 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 张领, 男, 主治医师, 主要从事心脏疾病的治疗。Tel:0375-4981117 Email:wchfeng @sina. com

Clinical evaluation of the efficiency of buflomedil hydrochloride injection in the treatment of the damage of peripheral nerve induced by diabetes

ZHANG Ling, JIE Xiao-Xia, WANG Su-Qin1   

  1. Cadre wards, The Second People's Hospital of Pingdingshan, Pingdingshan, Henan 467000;
    1Medicine Group of Pingdingshan City, Pingdingshan, Henan 467000
  • Received:2002-03-05 Revised:2002-05-01 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 观察盐酸丁咯地尔注射液治疗糖尿病性周围神经病变的疗效。方法: 糖尿病性周围神经病变患者56 例, 随机分为两组。丁咯地尔组( n = 28): 盐酸丁咯地尔150 mg 加入生理盐水250 ml, 静脉滴注, 每日1 次。常规治疗组( n =28): 采用常规治疗。两组用药持续15 d, 然后评价疗效和神经传导速度。结果: 丁咯地尔组症状明显改善, 总有效率为96. 5 %, 常规治疗组总有效率为57. 1 %, 两组差异具有显著性( P <0. 05), 并且盐酸丁咯地尔组神经传导速度明显提高( P <0. 01) 。结论: 盐酸丁咯地尔治疗糖尿病性周围神经病变疗效确切, 值得推广。

关键词: 盐酸丁咯地尔, 糖尿病, 周围神经病变

Abstract: AIM: To evaluate the efficiency of buflomedil hydrochloride injection ( Buf ) in the treatment of the damage of peripheral nerve induced by diabetes (DPN). METHODS: 28 patients with DPN were given Buf ( 150 mg·d-1, iv gtt) and another 28 patients were used routine therapy. The treatments lasted for 15 d. RESULTS: The total efficiency rate was 96. 5 % in Buf group, while it was 57. 1 % in routine therapy group ( P <0. 01). The conduction speed of nerve in buf group was greatly improved in comparison with the routine therapy ( P <0. 01). CONCLUSION: It is reliable for Buf to treat the damage of peripheral nerve induced by diabetes.

Key words: Buflomedil hydrochloride injection, diabetes, peripheral nerve

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