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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 347-348.

• 临床研究 • 上一篇    下一篇

放疗并局部注射IL-2 治疗鼻咽癌颈淋巴结转移残存的临床评价

梁平, 苏贞栋, 梁静英, 黄羽   

  1. 广西省玉林市红十字会医院肿瘤科, 玉林 537000
  • 收稿日期:2002-01-14 修回日期:2002-05-30 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 梁平, 男, 主治医师, 主要从事鼻咽癌防治工作。Tel:0775-2683411 E-mai l:lizhenlin183 @yahoo. com.cn

Clinical evaluation of radiotherapy combined IL-2 in the treatment of the transferred remnant of nasopharyngeal carcinoma in jugular lymph

LIANG Ping, SU Zhen-Dong, LIANG Jing-Ying   

  1. Department of Tumor, Yulin Redcross Hospital, Yuli, Guangxi 537000
  • Received:2002-01-14 Revised:2002-05-30 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 探讨鼻咽癌颈淋巴结转移残存放疗并局部注射IL-2 治疗的疗效。方法: 初治鼻咽癌患者颈部常规照射DA 6000-6800 cGy, 颈淋巴结转移残存对照组常规深X 线垂直局部加量照射DA1000 cGy,治疗组除常规加量照射外, 尚给予颈淋巴结残存局部基底注射IL-2 40 万u, 每周1 、3 、5 各1 次。结果: 治疗组和对照组的淋巴结消失率分别为93. 8 %和71. 0 %( P <0. 05); 满3 年后颈部无瘤生存率分别为66. 7 %和33. 3 %( P <0. 05); 1 、2 、3 年生存率在治疗组分别为73.8 %、59.5%、42.9 %, 在对照组为51.2 %、36. 6 %、22. 0 %( P <0. 05) 。两组副反应的差异无显著性。结论: 加量放疗并IL-2 局部注射治疗鼻咽癌颈淋巴结转移残存可以显著提高颈淋巴结转移的局部控制率, 是一种有效的治疗或补救治疗手段。

关键词: 鼻咽肿瘤, 放射疗法, 免疫治疗

Abstract: AIM: To evaluate the effects of radiotherapy combined IL-2 in the treatment of the transferred remnant of nasopharyngeal carcinoma in jugular lymph. METHODS: Treatment group ( n =32) was given radiation DA 6000-6800 cGy combined an injection of IL-2 4 ( 104 u ( three times each week). A routine radiation DA 6000-6800 cGy was adopted as a control group in another 31 cases. RESULTS: Lymph disappearance rate at treatment and control group reached 93. 8 % and 71. 0 %, respectively ( P < 0. 05); jugular humorless rate was 66. 7 % and 33. 3 %, respectively ( P <0. 05). The survival rates of 1, 2 and 3 year ( s) reached 73. 8 %, 59. 5 % and 42. 9 % in the treatment group, and 51. 2 %, 36. 6 % and 22. 0 % in the control group, respectively ( P <0. 05). The adverse actions did not show obvious difference between two groups. CONCLUSION: Incremental radiation combined partial injection of IL-2 is an effective remedy in the treatment of the transferred remnant of nasopharyngeal carcinoma in jugular lymph.

Key words: nasopharyngeal carcinoma, radiotherapy, immunotherapy, lymph

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