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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (4): 468-470.

• 研究原著 • 上一篇    下一篇

胸腔内注射金葡液治疗恶性胸水的疗效评价

任少华, 鲍行豪   

  1. 丽水市中心医院呼吸科,丽水 323000,浙江
  • 收稿日期:2003-02-08 修回日期:2003-02-22 出版日期:2003-08-26 发布日期:2020-11-19
  • 通讯作者: 任少华,男,副主任医师,主要从事呼吸系统疾病的防治研究工作。Tel:0578-2117438 E-mail:rrrsss@sina.com

Intrapleural injection of natural growth factor in the treatment of malignantPleural effusions

REN Shao-Hua, BAO Xing-Hao   

  1. Department of Respiratory,Lishui Central Hospital,Lishui 323000,Zhejiang,China
  • Received:2003-02-08 Revised:2003-02-22 Online:2003-08-26 Published:2020-11-19

摘要: 目的 观察金葡液(NGF)胸腔内注射治疗恶性胸水的疗效。方法 恶性胸水患者12 例,行常规胸腔穿刺术并尽量抽尽胸水后注入NGF 2 500 U,每周2 次。结果 CR 10 例,PR 2 例,总有效率100 %。随访3 ~ 25 mon,平均11.1 mon 。死亡11 例的平均生存时间为10.2 mon 。CR 中1 例无病生存达25 mon,另有2 例在分别在治疗后10 mon 和6 mon死亡,但未见胸水复发。与治疗前比较,胸腔注射NCF 后普遍出现周围血液淋巴细胞比例减少,而胸水淋巴细胞比例升高,未发现明显毒副作用。结论 胸腔内注射NGF 治疗恶性胸水的疗效确切,使用安全简便。

关键词: 药效学, 超抗原, 恶性胸水, 肺癌, 免疫疗法

Abstract: AIM: To investigate the therapeutic effects and the toxicity of intrapleural injection of natural growth factors(NGF,with main component of staphylococcal aureus enterotoxin C)in the treatment ofPatients with malignantPleural effusions.METHODS: Patients with histopathologically confirmed malignantPleural effusions were evaluated for treatment with NGF.TwelvePatients with malignantPleural effusions received NGFPleural instilations until the end of the survey.Drugs were administered according to the following schedule:NGF 2000 -2500 intrapleural injection twice weekly.The courses stopped whenPleural effusions disappeared or severe toxic reactions occurred.RESULTS: A total of 12 objective responses were assessed,including 10 complete responses(83 %),and 2Partial responses.Mean time of following uPwas 11.1(3 -25)months,11Patients died during the visit,and the mean survival time was 10.2 months,significantlylonger than that(<3months)inliterature.One of thePatients in CR grouPsurvived 25 months in a disease-free status; 2Patients died after 10 and 6 months respectively withoutlocal relapse.Compared withPretherapy,thePercentage oflymphocyte in the surrounding blood reduced while that inPleural effusions rose.No significant side effects were observed.CONCLUSION: The NGF intrapleural instillations are highly effective and well tolerated inPatients with malignantPleural effusions.

Key words: pharmacodynamics, superantigen, malignantPleural effusions, lung cancer, immunotherapy

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