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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (1): 107-109.

• 研究原著 • 上一篇    下一篇

草分枝杆菌联合顺铂治疗恶性胸腔积液的临床评价

王勇, 胡杰贵, 胡先纬   

  1. 安徽医科大学第一附属医院呼吸内科, 合肥 230022, 安徽
  • 收稿日期:2003-05-23 修回日期:2003-06-13 出版日期:2004-01-26 发布日期:2020-11-16
  • 通讯作者: 王勇,男, 主治医师, 硕士研究生。Tel:0551-5119520  E-mail: bking1008 @tom.com
  • 作者简介:胡杰贵, 男, 主任医师, 硕士生导师, 研究方向:肺癌早期诊断和治疗。Tel:0551-2922905

Clinical evaluation of mycobacterium phlei combined with cisplatin in treatment of patients with malignant pleural effusion

WANG Yong, HU Jie-Gui, HU Xian-Wei   

  1. Department of Pulmonary Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China
  • Received:2003-05-23 Revised:2003-06-13 Online:2004-01-26 Published:2020-11-16

摘要: 目的: 观察草分枝杆菌胸腔内注射治疗恶性胸腔积液的近期疗效、毒副反应及其对患者T 淋巴细胞亚群水平的影响。方法: 将62 例恶性胸腔积液患者随机分成试验组和对照组, 先尽量排完胸腔积液, 试验组向胸腔内注射生理盐水20 ml +草分枝杆菌8.6 μg +顺铂40 mg;对照组向胸腔内注射生理盐水20 ml +顺铂40 mg, 每周1 次, 连续1 ~ 3 次,1 mon 后观察疗效及治疗前后T 淋巴细胞亚群水平变化。结果: 试验组总有效率为87.5 %, 高于对照组(P<0.01), 毒副反应少而轻微。治疗后CD+3 、CD+4 及CD+4 CD+8 明显升高(P<0.01 或0.05),CD+8 显著降低(P<0.01) 。结论: 草分枝杆菌联合顺铂治疗恶性胸腔积液疗效肯定, 副反应少, 且能明显改善患者T 淋巴细胞亚群抑制状态。

关键词: 草分枝杆菌, 顺铂, 恶性胸腔积液, T 淋巴细胞亚群, 细胞免疫, 协同效应

Abstract: AIM: To evaluate the efficacy, safety and effects on changes of T-lymphocyte subsets of mycobacterium phlei and cisplatin in treatment of patients with malignant pleural effusion (MPE).METHODS: 62 patients of MPE were randomly assigned to two groups.The test group was treated once aweek lasting for 1-3 weeks with NS 20 ml +mycobacterium phlei 8.6 μg +cisplatin 40 mg, while the control one with NS 20 ml +cisplatin 40mg only.The efficacy and changes of T-lymphocyte subsets before and after therapy were analyzed separately.RESULTS: The overall response rate in the test group was 87.5 %, which meant significantly higher than that in the control group (P<0.01), and the side effects were mild.After the treatment, the levels of CD+3 and CD+4 cells and the ratio of CD+4 CD+8 increased greatly (P<0.05 or 0.01), while the level of CD+8 dropped sharply(P<0.01).CONCLUSION: The therapy of mycobacterium phlei combined with cisplatin is effective in controlling the MPE with low side-effect, and can greatly improve the inhibition of T-lymphocyte subsets in patients with MPE.

Key words: mycobacterium phlei, cisplatin, malignant pleural effusions, T-lymphocyte subsets, cellular immunity, immunotherapy, synergisitic effect

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