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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (5): 551-554.

• 研究原著 • 上一篇    下一篇

奎硫平与氯氮平治疗首发精神分裂症的疗效比较

王曼, 韩峰, 马欢   

  1. 中国医科大学精神医学教研室, 沈阳110000, 辽宁
  • 收稿日期:2004-02-21 修回日期:2004-03-10 发布日期:2020-11-22
  • 通讯作者: 王曼, 女, 助教, 研究方向:精神药理学。Tel:024-23256666-5355 E-mai l:wangman1976 @126.com

Comparation of quetiapine and clozapine in treatment of patients with first-onset schizophrenia

WANG Man, HAN Feng, MA Huan   

  1. Psychiatry Department of Chinese Medical University, Shenyang 110000, Liaoning, China
  • Received:2004-02-21 Revised:2004-03-10 Published:2020-11-22

摘要: 目的 比较奎硫平与氯氮平治疗首发精神分裂症的疗效与安全性。 方法 将首发精神分裂症患者85 例随机分为2 组, 分别给予奎硫平与氯氮平治疗, 其中奎硫平组43 例, 平均剂量为425 ±56 mg·d-1;氯氮平组42 例, 平均治疗剂量为350 ±73 mg·d-1, 疗程共8 周。采用阳性与阴性症状量表(PANNS) 及副反应量表(TESS) 在治疗前和治疗后第1、2、4、6、8 周末分别评定疗效和不良反应。 结果 两组治疗后第1、2、4、6、8 周末的PANNS 评分分别与治疗前比较, 均有显著减少(P <0.05 或P <0.01)。奎硫平与氯氮平有效率分别为88.4 %和83.3 %, 两者治疗计量范围分别为375 ~ 600 和300~ 475 mg·d-1。TESS 量表评定奎硫平组的不良反应明显小于氯氮平组。 结论 奎硫平治疗精神分裂症的起效时间与疗效与氯氮平相当, 不良反应明显小于氯氮平。

关键词: 奎硫平, 氯氮平, 精神分裂症, 疗效

Abstract: AIM: To compare the efficacy and safety between quetiapine and clozapine. METHODS: There were 85 patients with first on-set schizophrenia in this study, 43 patients treated with quetiapine 425 ± 56 mg·d-1 and 42 patients treated with clozapine 350 ± 73 mg·d-1.The study lasted for 8 wk.The Positive and Negative Symptom Scale (PANSS) and Treatment Emergent Symptom Scale (TESS) were used to evaluate therapeutic and side effects. RESULTS: The PANSS scores in both groups decreased significantly after treatment with those two drugs(P <0.05 or P <0.01).The rates of improvement were similar in quetiapine group and in clozapine group (88.4 % vs 83.8 %).The efficient dosages ranged from 375 to 600 mg·d-1 for quetiapine and from 300 to 475 mg·d-1 for clozapine.TESS showed quetiapine had fewer side effects than clozapine. CONCLUSION: Quetiapine has similar efficacy and the time before effect to clozapine in the treatment of schizophrenic with fewer side effects than clozapine.

Key words: quetiapine, clozapine, schizophrenia, efficacy

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