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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (1): 96-99.

• 研究原著 • 上一篇    下一篇

罗格列酮对高脂血症大鼠的胰岛素抵抗作用及其机制研究

郑琳颖, 潘竞锵1, 林洁茹, 肖柳英1, 李博萍, 韩超1   

  1. 广州市中医医院药剂科, 广州 510130, 广东;
    1广州市中医中药研究所药理研究室, 广州 510130, 广东
  • 收稿日期:2004-09-02 修回日期:2004-10-15 出版日期:2005-01-26 发布日期:2020-11-19
  • 通讯作者: 潘竞锵, 男, 副主任药师, 从事抗糖尿病药物和胰岛素增敏剂的药理研究。Tel:020-81953030 E-mail:zysgz@163.com
  • 作者简介:郑琳颖, 女, 主管中药师, 从事中药及药理学研究。Tel:020-81886504-2004 E-mail:pepper-mint@163.com

Effects and mechanisms of rosiglitazone on insulin resistance in rats with hyperlipemia

ZHENG Lin-ying, PAN Jing-qiang1, LIN Jie-ru, XIAO Liu-ying1, LI Bo-ping, HAN Chao1   

  1. Guangzhou Traditional Chinese Medicine Hospital, Guangzhou 510130, Guangdong, China;
    1Guangzhou Institute of Traditional Chinese Medicine, Guangzhou 510130, Guangdong, China
  • Received:2004-09-02 Revised:2004-10-15 Online:2005-01-26 Published:2020-11-19

摘要: 目的: 研究罗格列酮及格列齐特对高脂血症大鼠胰岛素抵抗的改善作用及其机制。方法: 建立高脂血症大鼠胰岛素抵抗模型, 并将其分为模型组、罗格列酮组和格列齐特组, 观察罗格列酮和格列齐特对其糖耐量减退、血清血糖血脂、TNF-α、Fins 含量、肝细胞TG 含量、脂质过氧化和肝肾功能等的影响。结果: 罗格列酮和格列齐特均有可能改善高脂血症致胰岛素抵抗模型病鼠的IGT 状态, 给药2 h后不同程度地降低病鼠FSG 及TNF-α浓度(P <0.05), 显著降低病鼠肝组织中TG 含量(P <0.01),明显抑制MDA 产生(P <0.01) 及增强GSH 贮量作用(P <0.01) 。罗格列酮还可降低病鼠高胰岛素水平及Fins 浓度(P <0.01), 明显降低病鼠BUN 和Cr含量(P <0.05), 提高ISI(P <0.01) 及增强SOD 活性(P <0.05) 。结论: 罗格列酮能改善高脂饲养引发的胰岛素抵抗。

关键词: 罗格列酮, 格列齐特, 胰岛素抵抗, 高脂饮食, 高脂血症, 大鼠

Abstract: AIM: To study the effects and mechanisms of rosiglitazone and gliclazide on insulin resistance in rats induced by high-fat diet and hyperlipemia. METHODS: After seven weeks feeding with high-fat diet, the rats with insulin resistance were divided into 3 groups:the control group, the rosiglitazone group and the gliclazide group.Insulin and glucose tolerance were tested.Concentrations of tumor necrosis factor-α(TNF-α) and fasting insulin (Fins) in serum and triacylglycerol (TG), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were determined in hepatic.RESULTS: The state of impaired glucose tolerance (IGT) was improved, the concentrations of fasting glucose (FSG), TNF-α, TG and MDA were decreased (P < 0.05), and the deposit of GSH were increased (P < 0.01) by rosiglitazone and gliclazide.The high insulin level and the concentrations of blood (BUN), creatine (Cr) and Fins were decreased and the sensitivity of insulin (ISI) (P <0.05) was increased by rosiglitazone. CONCLUSION: Rosiglitazone can improve the insulin resistance in rats induced by high-fat diet and hyperlipemia.

Key words: roglitazone, gliclazide, insulin resistance, high-fat diet, hyperlipemia, rats

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