内源性缩血管物质在糖尿病肾病形成中的变化情况及作用机制

摘要/Abstract

摘要： 糖尿病肾病(diabetic nephropathy, DN) 是糖尿病(diabetes mellitus, DM) 最主要的微血管病变之一。一系列血管活性物质参与了DN 的形成过程。本文综述近年来其中内源性缩血管活性物质在DN 发生发展过程中的变化情况及其作用机制, 并展望了该疾病潜在的治疗方向。

关键词: 血管紧张素Ⅱ, 内皮素-1, 血栓素A₂, 尿压素Ⅱ, 加压素, 糖尿病肾病, 机制

Abstract: Diabetic nephropathy (DN) is one of the most common microangiopathy complications in diabetes mellitus (DM). Many vasoactive substances are related to the development of DN. This article reviewed the mechanisms and changes of endogenous vasoconstrictive substances in the development of DN, also expected the possible treatment methods of DN.

Key words: angiotensin Ⅱ, endothelin-1, thromboxan A₂, urotensin Ⅱ, vasopressin, diabetic nephropathy, mechanism

中图分类号:

R587. 1

安娜芹, 丁选胜. 内源性缩血管物质在糖尿病肾病形成中的变化情况及作用机制[J]. 中国临床药理学与治疗学, 2008, 13(5): 589-595.

AN Na-qin, DING Xuan-sheng. Mechanisms and changes of endogenous vasoconstrictive substances in development of diabetic nephropathy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(5): 589-595.

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