表皮生长因子受体多态性对酪氨酸激酶抑制剂药效学影响的研究进展

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (8): 938-944.

表皮生长因子受体多态性对酪氨酸激酶抑制剂药效学影响的研究进展

王丽萍, 王果, 周宏灏

中南大学临床药理研究所,长沙 410078,湖南

收稿日期:2010-05-24 修回日期:2010-06-25 出版日期:2010-08-26 发布日期:2020-09-17
通讯作者: 周宏灏,男,院士,博士生导师,研究方向:遗传药理学和临床药理学。Tel: 0731-84805379 E-mail: hhzhou2003@163.com
作者简介:王丽萍,女,硕士研究生,研究方向:遗传药理学。Tel: 13787031694 E-mail: lpwang2009@163.com
基金资助:
国家自然科学基金资助项目(30901834,30801421,30672497,30472054);重大新药创制科技专项(2009ZX09501-032);湖南省科技计划项目(2009JT3020);教育部博士点(新教师)基金项目(20090162120024)

Epidermal growth factor receptor polymorphism development on pharmacodynamics of tyrosine kinase inhibitor

WANG Li-ping, WANG Guo, ZHOU Hong-hao

Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha 410078,Hunan,China

Received:2010-05-24 Revised:2010-06-25 Online:2010-08-26 Published:2020-09-17

摘要/Abstract

摘要： 目前表皮生长因子受体(EGFR)的酪氨酸激酶抑制剂(TKI)在治疗非小细胞肺癌中得到广泛应用。本文回顾了影响酪氨酸激酶抑制剂药效的EGFR基因多态性以及相关的EGFR基因突变位点对酪氨酸激酶抑制剂吉非替尼治疗非小细胞肺癌的药效发挥产生何种影响的相关研究,说明EGFR的基因多态性对酪氨酸激酶抑制剂的药效发挥产生了重要的作用。

关键词: 表皮生长因子, 受体多态性, 非小细胞肺癌, 酪氨酸激酶抑制剂, 吉非替尼

Abstract: At present, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor is extensively applicated in treatment of non small cell lung cancer(NSCLC). We review EGFR polymorphisms related to the pharmacodynamics of tyrosine kinase inhibitor(TKI), and the influence of pharmacodynamics of gefitinib, a typical drug of TKI. We conclude that the EGFR polymorphisms play an important role on the pharmacodynamics of TKI.

Key words: EGFR polymorphisms, NSCLC, Tyrosine kinase inhibitor, Gefitinib

中图分类号:

R968

王丽萍, 王果, 周宏灏. 表皮生长因子受体多态性对酪氨酸激酶抑制剂药效学影响的研究进展[J]. 中国临床药理学与治疗学, 2010, 15(8): 938-944.

WANG Li-ping, WANG Guo, ZHOU Hong-hao. Epidermal growth factor receptor polymorphism development on pharmacodynamics of tyrosine kinase inhibitor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(8): 938-944.

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