水飞蓟宾保护胰岛β细胞的作用及机制

摘要/Abstract

摘要： 水飞蓟宾是从水飞蓟中提取的一种黄酮类天然化合物,已用于多种疾病的治疗。近年来研究显示,水飞蓟宾对胰岛β细胞具有抗氧化、抗炎、改善糖脂毒性、增加胰岛素敏感性,改善胰岛素抵抗的作用,有可能成为潜在的糖尿病防治药物。

Abstract: A flavonoid extracted of milk thistle, silybin, is the most prescribed natural compounds, which is increasingly used in many kinds of diseases. Recent experimental studies have clearly demonstrated the effects of silybin on islets, its antioxidant, anti-inflammatory effects, and its effect of improving glucoliptoxicity, as well as its protective effect of improving insulin sensitivity and ameliorating insulin resistance. Therefore silybin seems a promising drug for diabetes mellitus.

Key words: Silybin, Insulin-secreting cells, Diabetes mellitus

中图分类号:

R587

徐君, 莫朝晖. 水飞蓟宾保护胰岛β细胞的作用及机制[J]. 中国临床药理学与治疗学, 2013, 18(4): 476-480.

XU Jun, MO Zhao-hui. Protective effect and mechanism of silybin on islet β-cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 476-480.

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