长链非编码RNA与系统性红斑狼疮的研究进展

doi:10.12092/j.issn.1009-2501.2018.04.018

摘要/Abstract

摘要：

在复杂的生物基因表达调节中，长链非编码RNA（lncRNA）曾被认为是“噪音”基因，如今却被认为在表观遗传学、染色质重塑、转录水平、转录后调控以及免疫系统调节过程中起到重要的调控作用。lncRNA参与调节免疫细胞的分化、活化和细胞因子的分泌表达等过程。本文主要介绍当前lncRNA在系统性红斑狼疮中所发挥的免疫调节作用。

关键词: 长链非编码RNA, 系统性红斑狼疮

Abstract:

Long noncoding RNAs (lncRNA), play significant role in regulation of epigenetics, chromatin remodeling, transcription and post transcriptional regulation and immune system regulation. Nonetheless, it once was seemed as "noise gene" among the complex modification of genetic functions. lncRNA is involved in the regulation of differentiation, activation and secretion of cytokines. In this study, we mainly focus on the role of lncRNA in the regulation of systemic lupus erythematosus.

Key words: long noncoding RNA, systemic lupus erythematosus

中图分类号:

R593.24

陈薪薪，陈朝生. 长链非编码RNA与系统性红斑狼疮的研究进展[J]. 中国临床药理学与治疗学, 2018, 23(4): 471-476.

CHEN Xinxin, CHEN Chaosheng. Research progress of long noncoding RNA in systemic lupus erythematosus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(4): 471-476.

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