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中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (1): 111-115.doi: 10.12092/j.issn.1009-2501.2019.01.019

• 综述与讲座 • 上一篇    下一篇

成纤维细胞生长因子-1治疗糖尿病及相关疾病的研究进展

金 辉1,周子晔1,梁 晶1,王陈翔1,宋林涛2,赵龙伟2,郭凯文2   

  1. 1 温州医科大学附属第一医院药学部,温州 325000,浙江;2 温州医科大学药学院,温州 325000,浙江
  • 收稿日期:2018-07-22 修回日期:2018-08-25 出版日期:2019-01-26 发布日期:2019-01-25
  • 通讯作者: 王陈翔,女,主管药师,主要从事临床药学研究。 E-mail:qiuqiuwcx@163.com
  • 作者简介:金辉,男,硕士,主管药师,主要从事医院临床药学工作。 E-mail:86694605@sina.com
  • 基金资助:

    温州市公益性科技计划项目(Y20160162)

Research progress of fibroblast growth factor 1 in the treatment of diabetes and related diseases

JIN Hui 1, ZHOU Ziye 1, LIANG Jing 1, WANG Chenxiang 1, SONG Lintao 2, ZHAO Longwei 2, GUO Kaiwen 2   

  1. 1 Department of Pharmacy of the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China; 2 School of Pharmacy of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  • Received:2018-07-22 Revised:2018-08-25 Online:2019-01-26 Published:2019-01-25

摘要:

酸性成纤维细胞生长因子(又称FGF-1)作为较早发现的成纤维细胞生长因子家族的重要成员,其刺激血管生长、加速创伤愈合和促进神经损伤修复等作用已被广泛认可,近年来它在内分泌系统中潜在的生物学功能的研究也成为热点。本文就FGF-1的结构功能、受体信号转导通路及对糖尿病的治疗作一综述。

关键词: 成纤维细胞生长因子-1, 糖尿病

Abstract:

Acid fibroblast growth factor (FGF-1) as found earlier as an important member of fibroblast growth factor family, which stimulates the growth of blood vessels, accelerate wound healing and promote nerve injury repair has been widely recognized before,in recent years, research on the potential biological function of it in endocrine system has become a hot point. This article will review the FGF-1 about structure, function, receptor signaling pathway and treatment of diabetes and related diseases.

Key words: fibroblast growth factor 1, diabetes

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