Exosomes (Exos) are nano-sized membrane vesicles actively secreted by adipose-derived mesenchymal stem cells (ADSCs), carrying bioactive molecules such as long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA), which are non-coding RNAs (ncRNA) that enter into the corresponding target cells and participate in intercellular communication. ADSC-Exo-ncRNA can regulate the immune and inflammatory response, angiogenesis, accelerate skin cell proliferation and epithelialization, and regulate collagen remodeling, thereby enhancing wound repair ability. Therefore, ADSC-Exo-ncRNA exerts an significant role in the process of wound repair and provides a promising strategy for treatment. In this paper, we review the role of ADSC-Exo-ncRNA in wound healing and its application prospects in recent year.