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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2025, Vol. 30 ›› Issue (7): 977-983.doi: 10.12092/j.issn.1009-2501.2025.07.013

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Research progress on the clinical application and mechanism of commonly used traditional Chinese medicine in the treatment of breast cancer

LI Shanshan1,2, WEI Dandan3, KANG Hanyu2, LIU Xiaopeng2, YAN Shuxun1, JIANG Shiqing2   

  1. 1Endocrinology Department Ward of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China; 2The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China; 3Acupuncture Pain Department of First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China
  • Received:2024-09-03 Revised:2025-01-18 Online:2025-07-26 Published:2025-07-02

Abstract:

Breast cancer is a common clinical gynecological tumor. According to the 2022 global cancer data statistics, breast cancer ranks second in terms of incidence among newly diagnosed cancer cases worldwide. Modern medicine often adopts surgical operation, chemotherapy, and other methods, which have certain efficacy but also many problems such as high drug resistance rates and significant adverse reactions. Chinese patent medicines exhibit extensive anticancer effects. The study found that Shenyi Capsule, Pingxiao Capsule, and Zhenqi Fuzheng Granules were widely used in the treatment of breast cancer, exerting therapeutic effects on breast cancer by inhibiting cell proliferation, invasion, and metastasis, suppressing angiogenesis, reversing cellular drug resistance, and inhibiting precancerous lesions. Meanwhile, the oral administration of Chinese patent medicines in combination with other traditional Chinese medicine (TCM) compounds, TCM decoctions, or modern medical treatments can improve patients' quality of life and reduce adverse reactions. Currently, there are numerous studies on the treatment of breast cancer with Chinese patent medicines, but a systematic summary is lacking. Therefore, this study conducted a systematic review of the mechanisms of action and clinical applications of Chinese patent medicines as adjuvant therapy for breast cancer, aiming to provide guidance for clinical medication.

Key words: breast cancer, Chinese patent medicine, mechanism of action, clinical application

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