Progress in research on macrophage polarization, intestinal flora and their metabolites in organ injury

doi:10.12092/j.issn.1009-2501.2026.01.014

Abstract

Abstract:

Macrophage polarization, intestinal flora and their metabolites have emerged as research hotspots in recent years. Several published studies have shown that there is a certain correlation between macrophage polarization and intestinal flora as well as their metabolites. Intestinal flora and their metabolites can induce macrophages to polarize into M1 or M2 phenotypes, thereby triggering pro-inflammatory or anti-inflammatory responses, which are closely related to organ injury. This review summarizes the relevant research on macrophage polarization, intestinal flora, and their metabolites in organ injury. It elaborates on the mechanisms and related pathways of macrophage polarization, explores the regulatory effects of intestinal flora and their metabolites on macrophage polarization, and discusses their roles in related diseases and organ injury. The aim is to provide new insights for the research on the mechanisms of organ injury and corresponding protective strategies.

Key words: macrophage polarization, intestinal flora, metabolites, inflammation, organ injury

CLC Number:

Yiru WEN, Jinlamu YANG, Ga MEI, Na LI, Yapeng LU, Yan ZHANG, Jieting LIU. Progress in research on macrophage polarization, intestinal flora and their metabolites in organ injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(1): 125-132.

Figures/Tables 2

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