Abstract: Aim The effect of lacidipine for patients with essential hypertension and its effect on plasma endothelin and angiotensin Ⅱ level were observed. Methods Forty patients with essential hyper-tension were treated with lacidipine 4-8 mg 1/d,for 4 weeks. Ambulatory blood pressure monitor-ing(ABPM) was carried out in 20 patients. Result The responsive rate was 67.5%,the total ef-fective rate was 92. 5%. SBP,DBP and MAP were decreased 28. 40,19.7 and 22. 7 mmHg,re-spectively. The total effective rate in patients with essential hypertension in stage I, Ⅱ was higher than that in patients in stage Ⅲ. We also found the plasma endothelin and angiotensin I level were decreased after lacidipine treatment. Conclusion The results suggest that lacidipine is a drug of stabilization, persistance, low dose (1/d) and good toleration for the treatment of essential hypertension.

Key words: Lacidipine, Hypertension, Endothelin, Angiotensin Ⅱ