Abstract: Aim The effect of Kang shuailing mixture on ability of learning and memory of mice was observed.Methods Mice were given different chemical substances to build special experimental models.With the methods of passive avoidance reaction (stePdown test,stePthrough test and labyrinth test)the action of Kang shuaining mixture was observed.Results The experiment show ed that Kang shuaining mixture could decrease the learning disorder caused by scopolamine,promote the ability of memory of mice with spaceorientation disorder caused by per tobarbital sodium,and antagonize disorder of memory consolidation induced by sodium nitrite and disorder of memory reappearance induced by ethanol.Conclusion Kang shuaining mixture possess obvious effects on learning and memo rypromotion at different levels.

Key words: Kangshuaining mixture, mice, memory, step down test, step through