Abstract: Aim and Methods To observe the effects of sasanquasaponin(SQS)on the activities of Ca²⁺-Mg²⁺-ATPase and Na⁺-K⁺-ATPase and the contents of Na⁺, Ca²⁺ and Mg²⁺ in ischemic myocardial mitochondria of rats, my ocardiali schemiarat model was induced by subcutaneous injection of isoprote renol (ISO, 4 mg · kg^-1)and some model rats were given SQS (0.2 mg · kg^-1)once daily for 3 days.Results As compared with those in the control, myocardial mitochondrial Mg²⁺ content was markedly reduced, while the contents of Na⁺ and Ca²⁺dramatically increased and the activities of Ca²⁺-Mg²⁺-ATPase and Na⁺-K⁺-ATPase were decreased significantly in ischemic rats administering SQS(0.2 mg · kg^-1, iv).Conclusions QS has cytopretectiveef ect by antagonizing the overload of Na⁺, Ca²⁺ in ischemic myocardial mitochondria.

Key words: sasanquasaponin, magnesium, calcium, sodium, myocardial protection