Abstract: Aim To explore the ant i-fibrotic mechanism of Radis Astragali, we observed the ICAM-1 and CD126 expression affected by Radis Astragali in human fibro blasts.Methods Different do sages of Radis Astragali were added in the mediums for fibroblast culture.The ICAM-1 and CD126 positive cells were assessed by using flow cytometry.Results Positive rate of ICAM-1 and CD 126 in normal cultural fibroblasts was 82.63±5.94 and 77.95±4.68 respect ively.It decreased in cultural fibroblasts with Radis Astragali.Conclusion Radis Astragali can inhibit the immune-adhensive function of fibroblasts, which may-be one of its anti-fibrotic mechanisms.

Key words: radis as trag ali, fibroblast, cell culture, ICAM-1, CD126