Abstract: Aim The antipyretic and anti-inflammatory effects of Niu Huang Qian Jin San was explored.Methods (1)The anti-inflammatory effect of Niu Huang Qian Jin San was tested by using the method of swelling rat toes;(2)The antipyretic effect of Niu Huang Qian Jin San was determined by the method that colitox in was injected into rabbit's auricular vein.Results (1)Niu Huang Qian Jin San has manifest anti-inflammatary effect. After using the medicinc, there is much more difference of the swelling degree of the rat toes than that of NS(P<0.01).(2)Niu Huang Qian Jin San can streng then the antipyretic effect of aminopyrine CO. There is very remarkable difference of the centigrade temperature rising between the group injected Niu Huang QIan Jin San and the comparison group injected NS.Conclusion Niu Huang Qian Jin San solution has significant antipyretic and anti-inflammatory effects.

Key words: Niu Huang Qian Jin San, antipyrelic effect, anti-inflammatory effect