Abstract: Aim The study is to observe the clinical efficacy of losartan in hypertentive patients with left ventricular hypertrophy. Methods 21 case were given losartan for 20 wk and 24 h ambulatory blood pressure monitoring and color doppler echocardiography were performed in the patients before and after treatment.Results The24hSBP,24hDBP,dDBP, nSBP were from (151土15)、 (93士9)、(155土15)、(96土10)、(146士16)、(88士11)mmHg before treatment to (132士11)、(82士8)、(137士12)、(88士9)、(120土9)、(120士15)、(74士9) mmHg after treatment respectively and the IVST, PWT and LVMI were from (14.2土1.5) mm、(13.9土1.45) mm、(152.1+24.2) g·m^2-1 BSA before treatment to (12.1土1.31) mm、(12.2士1.41) mm、(130.6+23.1) g·m^2-1 BSA after treatment respectively.. All the parameters after treatment in the patients were significantly decreased as compared with those before treatment (P<0. 01).Conclusion Losartan can significantly lower the blood pressure and the left ventricular hypertrophy in hypertensive patients with left ventricular hypertrophy.

Key words: hypertension, left ventricular hypertrophy/drug therapy, losartan/therapyuse, ambulatory blood pressure monitoring, color doppler echocardiography/methods