Abstract: Aim To evaluate the antianginalcy of trimetazidine in combination with other regular antiischemic drugs in the treatment of stable angina. Methods Twenty-two male cases with stable, effortinduced angina and positive exercise ECG test were treated with trimetazidine for 12 weeks.Exercise ECG test was ex amined again in the end of the study. Results There were obviously increased in exercise tolerance, total exercise workload after treatment (P<0.01, all), and there were also significant prolong ation of the duration of angina pectoris, improvement in ST segment depressing at peak exercise (P<0.01).Average number of chest pain per week and nitrog lycerin consumption obviously decreased (P<0.01).Conclusion There is obvious anti-ischemic efficacy of trimetazidine in combination with other antianginal drugs.

Key words: trimetazidine, my ocardial ischemia, angina, exercise test