Abstract: Aim To observe the effect of valsartan and benazepril on the activities of Na⁺-K⁺-ATPase and Ca²⁺-ATPase in myocardium of spontaneously hypertensive rats (SHR).Methods Twenty-four SHR were divided into the NS, benazepril, valsartan 8 mg·kg^-1 and valsartan 24 mg·kg^-1 groups, with 6 Wistar Kyoto rats(WKY) serving as control.after 4 experimental weeks, the activi ties of Na⁺-K⁺-ATPase, and Ca²⁺-ATPase as well as associated indexes were measured.Results (1) The activities of Na⁺-K⁺-ATPase and Ca²⁺-ATPase in myocardium of SHR were no tably lower than those of WKY rats; (2) Both valsartan and benazepril increased activity of Na⁺-K⁺-ATPase in myocardium of SHR;(3) The increase of activity of Ca²⁺-ATPase was observed only in 24 mg·kg^-1 valsartan group.Conclusion Valsartan and benazepril elevate the activity of Na⁺-K⁺-ATPase in myocardium of SHR.But the elevation of Ca²⁺-ATPase activity is observed only in large dose of valsartan.

Key words: spontaneously hypertensive rat, Na⁺-K⁺-ATPase, Ca²⁺-ATPase, valsartan, benazepril