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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (2): 143-146.

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Relationship between left ventricular hypertrophy (LVH) and hyperinsuli-naemia in patients with primary hypertension1

HONG Hua-Shan, WANG Yi-Bo, LIN Lan, JIANG Qiong, ZHENG Guan-Yi2   

  1. Department of Cardiology,2Department of Traditional Medicine, Union Hospital affiliated to Fujian Medical University,Fuzhou 350001
  • Received:2002-01-31 Revised:2002-02-25 Online:2002-04-26 Published:2020-11-27

Abstract: AIM: To evluate the relation of LVH to the fasting insulin in untreated primary hypertensive pa-tients.METHODS: 83 cases of newly diagnosis and un-treated hypertensive patientswere divided into two groups (LVH group and LV normal group) according to the left ventricular mass index (LVMI) which was measured and calculated by echocardiography.The fasting insulin, lipids, glucose, creatine and urine nitrogen were assayed and compared between two groups.RESULTS: The lev-els of fasting triglyceride and insulin in LVH group were higher than LV normal group while the insulin sensitivity index was lower than the latter.The multifactor regression analysis showed that only insulin was positively correlated to LVH in primary hypertensive patients (r=0.49, P < 0.01).CONCLUSION: That hyperinsulinemia is close-ly correlated with and involvement in the pathogenesis of left ventricular hypertrophy in patients with primary hy-pertension.

Key words: primary hypertension, left ventricular hypertrophy (LVH), insulin, metabolism disorder

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