Abstract: AIM: To observe the recent curative ef-fect of basic fibroblast growth factor (bFGF) to patients with recurrent aphthous ulcer (RAU).METHODS: 60 patients with RAU were treated by locally spraying com-pound bFGF preparations composing of calculated quantity of bFGF, tinidazole and dicaine on the surface of ulcera-tions, other 40 patientswere treated by alternatively smear-ing Xi Leisan and Smecta on the surface of ulcerations as routine treatment group, tid, for 5 d.RESULTS: The improvement of three indexes including the size, the de-gree of ache and hyperemia of the ulcerations are greater in compound bFGF treatment group than those in routine treatment group (P<0.001), and the effectiverate was also higher in bFGF treatment group (86.67 %) than those in (65.00 %) routine treatment group (P<0.05). No significant side effect was observed during the treat-ment with compound bFGF.CONCLUSION: The com-pound bFGF preparations usedin this study is effective and safe for the treatment of RAU.

Key words: basic fibroblast growth factor, tinida-zole, dicaine, aphthous ulcer