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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (3): 279-282.

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Advances of pharmacokinetic studies of topiramate, a new antiepileptic a-gent

HE Xi-Mei, HE Xin, ZHANG Er-Huai   

  1. Medical Laboratory Center, School of Medicine, Zhengzhou University, Zhengzhou 450052
  • Received:2001-12-28 Revised:2002-03-08 Published:2020-12-01

Abstract: The article introduced advances of pharma-cokinetic studies of topiramate, a new antiepileptic agent, in recent years.Topiramate pharmacokinetic parameters were determined after the administrations of single dose, multiple dose and concomitant therapy.The changes of its pharmacokinetic parameters were determinedin the influ-ence of the factors, for example, age, disease, and so on.These results haverevealed the regulations of metabolism and excretion of topiramate in the healthy vol-unteers and patients.The data provide a basis of clinical rational medication for the patiens with epilepsy. KEY WORDS:topiramate;epilepsy;pharmacokinetics

Key words: topiramate, epilepsy, pharmacokinetics

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