Abstract: AIM: To observe the effect of sibutramine in the treatment of obesity with different body weight. METHODS: Forty overweight subjects were divided into three groups according to their BMI: Group 1 ( n =10), the early stage of obesity; Group 2 ( n =11), obesity in degree Ⅰ; and Group 3 ( n =19), obesity in degree Ⅱ. The patients conformed to the same standards of diet, sports and life style, and then took sibutramine 10 mg a day for 12 weeks. RESULTS: After taking the medicine for two weeks, the efficacy rate was 45. 5 %( 5) in Group 2 and 94. 7 % ( 18) in Group 3 ( P <0. 01); four weeks later, 81. 8 % ( 9) in Group 2 and 5. 8 % ( 3) in Group 3; the obvious effect rate was 9. 1 % ( 1) in Group 2 and 84. 2 % ( 16) in Group 3 ( P <0. 01). After 12 weeks, the efficacy rate was 55. 6 % ( 5) in Group 1, 36. 4 % ( 4) in Group 2; the obvious effect rate was 63. 6 % ( 7) in Group 2 and 100 % ( 19) in Group 3 ( P <0. 01). CONCLUSION: Sibutramine is safe and efficient in the treatment of obesity with different body weight. The effect increases with body weight increasing.

Key words: sibutramine, BMI, obesity