Clinical evaluation of the efficiency of controlled-release formulation of glipizide in the treatment of type II diabetes mellitus

Abstract

Abstract: AIM: To compare the efficacy between a once-daily controlled-release formulation of glipizide ( CRFG) and immediate-release glipizide ( IRG) in patients with type Ⅱ diabetes mellitus. METHODS: 80 patients with type Ⅱ diabetes mellitus were divided into the CRFG group and the IRG group to observe the levels of blood glucose and insulin after the treatments. RESULTS: CRFG given qd and IRG given bid or tid showed a similar effect, but the levels of fasting and post prandial insulin in latter was higher than that in the former. CONCLUSION: The controlled-release formulation of glipizide can effectively control blood glucose without hyperinsulinemia in patients with type Ⅱ diabetes mellitus.

Key words: glipizide, blood glucose, type Ⅱ diabetes mellitus

CLC Number:

969.3

WANG Zhan-Jian, WANG Yan, SONG Qing-Fang, LIU Bo, ZHOU Ya-Ru. Clinical evaluation of the efficiency of controlled-release formulation of glipizide in the treatment of type II diabetes mellitus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(4): 334-336.

[1]	YAO Jia, QIAO Di, GUO Xin, CUI Changmeng. Therapeutic effects of 1-Deoxynojirimycin in mulberry leaves on rats with diabetic nephropathy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(5): 517-523.
[2]	CHEN Li, HOU Yong, DU Tian-xi, LI Shao-yin, WANG Guang-ming, ZHU Bang-liu, HUANG De-wu. Effects of Bisphenol A on metabolismof glucose and lipid in mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(3): 265-270.
[3]	CHEN Zi-miao, CHEN Xiao-jun, WANG Mei-rong, PAN Liang-liang, HU Wan-li, NI Lian-song. Effect of Ketotifen on pancreatic function of streptozotocin-induced type 2 diabetic rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(6): 627-632.
[4]	LIU Yi, CHEN Jie, CHI Li-fang. Study on clinical effect of Yiqi Yangyin prescription imposed on gestational diabetes mellitus and perinatal outcome [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 408-412.
[5]	YAO Gui-lian, GAO Fen-fei, SHI Gang-gang. Research development in the functions of the nuclear transcription factor E47 [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(4): 437-442.
[6]	YANG Jing-jing, SUN Hua, ZHAO Jun, DAI Min, LI Xiang-hong, ZHAO Ya-nan, LU Jian-ping, XIE Hai-tang. Determination of Pidotimod in Human Serum by HPLC-MS/MS [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(3): 308-312.
[7]	ZHOU Peng, SUN Yuan, ZHANG Shu-xia, XIA Ai-xiao, CHEN Sai-zhen, DU You-gong. Pharmacokinetic study of glipizide effected by roxithromycin in rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(2): 181-184.
[8]	WANG Jie-sheng, WANG Qin-xian, CHEN Fu-xin, LI Hong-chun, LUO Ke-xue. Somatostatin-induced hyperglycemia in case of diabetes and pharmacology analysis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(11): 1260-1263.
[9]	WU Ling-ling, FAN Jian-hui, YIN Yu-zhu, WANG Lin-lin, ZHU Juan, HOU Hong-ying. Clinical study of sufentanil combined ropivacaine for labor pain in gestational diabetes mellitus [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(8): 920-923.
[10]	TAN Hong-yi, SONG Min, YANG Guo-ping, HUANG Zhi-jun, LIU Chang, YANG Li, XIANG Hong, FU Zhi-min, HUANG Yuan-yuan. Pharmacokinetic and pharmacodynamic studies on repaglinide in healthy Chinese volunteers [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(9): 979-983.
[11]	YUAN Lin, YAN Tian-hua, WANG Qiu-juan, GUO Qing-long. Effect of Exendin-4 on the glucose tolerance and serum glucose level in normal animals [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(3): 296-299.
[12]	ZHANG Xin-yue, LI Qin, CHEN Ai-jun, NI Ya. Experimental studies on hypoglycemic activity of active hepatin [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(8): 847-851.
[13]	MA Xue, HUI Hong-xiang, LIU Zhen-guo, WU Yu-mei, MENG Jia, LUO Xiao-xing. Effects of glucagon-like peptide-1 prodrug on glycemia control in non-diabetic mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(1): 28-31.
[14]	XIA Li-Bin, HUANG Xiao-Hui, SUN Rui-Yuan. Intervention of bennazepril in the patients with impaired glucose tolerance [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(9): 1061-1064.
[15]	XIA Li-Bin, LU Mei-Qin, ZHANG Bin-Hua, ZHANG An-Su, CHEN Yue-Ping, HUA Qiang, MAO Guo-Guang. Clinical evaluation on efficacy of domestic nateglinide tablet in patients with type 2 diabetes mellitus [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(8): 932-934.

Clinical evaluation of the efficiency of controlled-release formulation of glipizide in the treatment of type II diabetes mellitus

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments