Abstract: AIM: To explore the efficacy of salbutamol combined with magnesium sulfate by nebulization in the treatment of paroxysmal asthma. METHODS: All of 75 asthma patients were divided into three groups of A, B, and C (n =25):A group treated with 3ml of 7.5 % isoosmotic magnesium sulfate solution and 3ml of physiology saline 5 minutes later;B group treated with 3 ml of 0.1 % salbutamol solution and 3ml of Physiology saline 5 minutes later;C group treated with 3 ml of 0.1 % salbutamol solution and 3 ml of 7.5 % isoosmotic magnesium sulfate solution 5 min later.Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF) in the three groups were tested before and after the treatment 15min respectively;systolic, diastolic, heart rates and respirations were tested between group A and group C as well. RESULTS: Significant differences were found in ratios (FVC %, FEV1 %, PEF %) of actual indexes of lung function (FVC, FEV1, PEF) to the predicted indexes between before and after treatment in the three groups (P < 0.05).The lung function of B group was higher than that of A group (P <0.05) and C higher than A and B (P < 0.01).There was not significant difference between A and C groups in systolic, diastolic, heart rates and respirations before and after treatment (all of P <0.05). CONCLUSION: There is a synergism in the nebulization inspirating of 0.1 % salbutamol combined with 7.5 % isoosmotic magnesium sulfate in the treatment of paroxysmal asthma.It can improve ventilation function, but does not affect the blood pressure, heart rates and respirations.

Key words: asthma, magnesium sulfate, salbutamol, nebulization