Abstract: AIM: To observe the effects and safety of clopidogrel used in percutanous coronary intervention(PCI)while acute occlusions of coronary arteries happened.METHODS: 92 patients with acute occlusions of coronary arteries were treated through PCI and they were randomized equally into following groups:clopidogrel group(CPG group)and ticlopidine group(TCpgroup).Each patient was treated with clopidogrel 25 mg bid or ticlopidine 250 mg bid for 4 weeks after PCI.RESULTS: Compared with the control group,there was not significantly difference in platelet aggregation(45.36±2.98 vs 51.60±2.56)and clinical effects(97.95% vs93.02%)after 3 weeks.The proportion of patients with adverse events who had to release the treatment was2.04%(CPG group)and 16.27%(TCpgroup).CONCLUSION: The clinical effect of clopidogrel is similar to ticlopidine and shows less adverse events.

Key words: clopidogrel, ticlopidine, acute occlusions of coronary arteries