Abstract: AIM: To establish a HPLC method to determine nifedopine the content and uniformity of nifedopine tablet.METHODS: HPLC condition was set as ODS column,flow phase:methanol-water(60 ∶40),flow rate:0.8 ml·min^-1,and detection wavelength:235nm.RESULTS: The nifedopine linear range was 0.020-0.200 g ·L^-1 in this method.The average recovery rates were 99.6%,98.9%,and 100.4% in high,normal and low concentrations,respectively.The corresponding values of RSD were 0.42%,0.54% and 0.35%(n=5).CONCLUSION: This HPLC method shows a high specificity and sensitivity,and is accurate,simple and rapid in performance.

Key words: HPLC, content determination, nifedopine