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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (3): 337-339.

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Effects of caffeic acid, ferulic acid and vanillic acid on tyrosinase

YAN Jun, LI Chang-Sheng, CHEN Sheng-Li1, ZHANG Jun-Ren2   

  1. Department of Pharmacy, Jinan Hospital for Skin Diseases Prevention, Jinan 250001, Shandong, China;
    1Department of Dermatology, Shandong Provincial Institute of Dermatology and Venereology, J inan 250022, Shandong, China;
    2Department of Pharmaceutical Analysis, School of Pharmacy, Shandong University, Jinan 250012, Shandong, China
  • Received:2003-10-13 Revised:2003-11-28 Online:2004-03-26 Published:2020-11-21

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Abstract: AIM: To evaluate the effects of monomers of caffeic acid, ferulic acid and vanillic acid on the activity of tyrosinase, so as to provide a kind of drug in the treatment of hyperpigmentation.METHODS: Tyrosinase activity was estimated by measuring the oxidation rate of L-DOPA.The inhibitory pattern of each monomer was determined according to their Lineweaver-Burk curve compared to the controlled group.RESULTS: Vanillic acid showed an inhibition to tyrosinase activity, and the rate of inhibitory was similar to hydroquinone, which had no statistically significant difference between them (P >0.05). Caffeic acid and ferulic acid showed an up-regulation to tyrosinase activity.CONCLUSION: Vanillic acid, a mixed-type inhibitor of tyrosinase, can inhibit the activity of tyrosinase greatly.

Key words: caffeic acid, ferulic acid, vanillic acid, tyrosinase, inhibitor

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